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Expression of glutathione S-transferase-pi in human squamous cell carcinomas of the pharynx and larynx. Loss after radiation therapy.

Authors
  • Tanita, J
  • Tsuchida, S
  • Hozawa, J
  • Sato, K
Type
Published Article
Journal
Cancer
Publication Date
Jul 15, 1993
Volume
72
Issue
2
Pages
569–576
Identifiers
PMID: 8319189
Source
Medline
License
Unknown

Abstract

The results suggest that although GST-pi expression is not directly involved in determining sensitivity to radiation, GST-pi expression can be influenced by exogenous agents. The loss or decrease of GST-pi after irradiation is in clear contrast to the enhanced expression observed in many cancer cell lines resistant to chemotherapy.

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