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Expression of glucose transporters in the developing rat skin.

Authors
  • Oh, Chang Seok1
  • Hong, Jong Ha1
  • Jin, Shun Nu1
  • Lee, Wang Jae1
  • Lee, Young Soo2
  • Lee, Eunju2
  • 1 Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, Korea. , (North Korea)
  • 2 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. , (North Korea)
Type
Published Article
Journal
Anatomy & cell biology
Publication Date
Sep 01, 2017
Volume
50
Issue
3
Pages
214–218
Identifiers
DOI: 10.5115/acb.2017.50.3.214
PMID: 29043100
Source
Medline
Keywords
License
Unknown

Abstract

We found the changed distribution of glucose transporter (GLUT) proteins in the skin during rat development. At 15 days of gestation, GLUT1 and 2 proteins were expressed in the stratum corneum of epidermal cells. In postnatal skin, however, GLUT1 and 2 exhibit different expression patterns. While GLUT1 expression becomes more restricted to the stratum basale with development, GLUT2 was found mainly in stratum spinosum and granulosum, but not being localized in the stratum basale at any stages of perinatal skin development. Considering all these, it can be speculated that each GLUT protein plays its specific role in different epidermal layers and that the glucose used in mammalian skin in utero could be originated from the amniotic fluid during skin development.

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