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Expression and function role of DNA methyltransferase 1 in human bladder cancer.

Authors
  • Wu, Chun-Te1
  • Wu, Ching-Fang
  • Lu, Chang-Hsien
  • Lin, Cheng-Chia
  • Chen, Wen-Cheng
  • Lin, Paul-Yang
  • Chen, Miao-Fen
  • 1 Department of Urology, Chang Gung Memorial Hospital, Keelung, Taiwan. , (Taiwan)
Type
Published Article
Journal
Cancer
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 15, 2011
Volume
117
Issue
22
Pages
5221–5233
Identifiers
DOI: 10.1002/cncr.26150
PMID: 21523767
Source
Medline
License
Unknown

Abstract

DNMT1 could be a significant clinical predictor for stage and treatment response of bladder cancer. Moreover, targeting this enzyme could be a promising strategy for treating bladder cancer, as evidenced by inhibited tumor growth and enhanced radiosensitivity.

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