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Expression and function of inducible costimulator on peripheral blood T cells in patients with systemic lupus erythematosus.

Authors
Type
Published Article
Journal
Rheumatology (Oxford, England)
Publication Date
Volume
44
Issue
10
Pages
1245–1254
Identifiers
PMID: 15987711
Source
Medline
License
Unknown

Abstract

Hyperexpression of ICOS on peripheral blood CD4 and CD8 T cells from patients with SLE contributed to the dysregulated T-cell proliferation, T-cell activation and pathogenic autoantibody production, which showed that the abnormality of ICOS costimulation may play an immunopathological role(s) in the pathogenesis of SLE.

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