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Expression and function of inducible costimulator on peripheral blood T cells in patients with systemic lupus erythematosus.

Authors
  • Yang, Jia-Hui
  • Zhang, Jun
  • Cai, Qing
  • Zhao, Dang-Bao
  • Wang, Jian
  • Guo, Ping-E
  • Liu, Li
  • Han, Xing-Hai
  • Shen, Qian
Type
Published Article
Journal
Rheumatology (Oxford, England)
Publication Date
Oct 01, 2005
Volume
44
Issue
10
Pages
1245–1254
Identifiers
PMID: 15987711
Source
Medline
License
Unknown

Abstract

Hyperexpression of ICOS on peripheral blood CD4 and CD8 T cells from patients with SLE contributed to the dysregulated T-cell proliferation, T-cell activation and pathogenic autoantibody production, which showed that the abnormality of ICOS costimulation may play an immunopathological role(s) in the pathogenesis of SLE.

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