Expression of Fas ligand in newly diagnosed childhood acute lymphoblastic leukemia.
- Published Article
- Publication Date
Jan 01, 1999
Immunocytochemistry was used to analyze the expression of the Fas ligand (FasL) in sixty-four children with newly diagnosed acute lymphoblastic leukemia (ALL). FasL expression was detected in 55 of 64 children (86%). Children with newly diagnosed ALL and FasL expression exhibited longer relapse-free and overall survival times under chemotherapy than did patients who did not express the Fas ligand. These data suggest that Fas/FasL mediated signaling may play a general role in the cytotoxicity of anticancer drugs.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/10629626