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Expression of cytochrome P450 CYP1B1 in breast cancer.

Authors
  • McKay, J A
  • Melvin, W T
  • Ah-See, A K
  • Ewen, S W
  • Greenlee, W F
  • Marcus, C B
  • Burke, M D
  • Murray, G I
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 30, 1995
Volume
374
Issue
2
Pages
270–272
Identifiers
PMID: 7589551
Source
Medline
License
Unknown

Abstract

The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.

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