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Expression of the anaphylatoxin C5a receptor in the oligodendrocyte lineage.

Authors
  • Nataf, S
  • Levison, S W
  • Barnum, S R
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Mar 16, 2001
Volume
894
Issue
2
Pages
321–326
Identifiers
PMID: 11251209
Source
Medline
License
Unknown

Abstract

Expression of the C5a receptor in the central nervous system has been demonstrated on microglia, astrocytes and neurons. In the present study, we demonstrate C5aR expression in vitro by rat and murine O2-A progenitor cells and oligodendrocytes. We also observed that in vitro differentiation of O2-A progenitors into mature oligodendrocytes is accompanied by down-regulation of C5aR mRNA expression. These results suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in oligodendrocyte function.

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