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Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis.

Authors
  • Forghanifard, Mohammad Mahdi
  • Moaven, Omeed
  • Farshchian, Moein
  • Montazer, Mehdi
  • Raeisossadati, Reza
  • Abdollahi, Abbas
  • Meysam Moghbeli
  • Nejadsattari, Taher
  • Parivar, Kazem
  • Abbaszadegan, Mohammad Reza
Type
Published Article
Journal
Annals of Surgical Oncology
Publisher
Springer - Society of Surgical Oncology
Publication Date
March 2012
Volume
19
Issue
3
Pages
743–749
Identifiers
DOI: 10.1245/s10434-011-2074-8
PMID: 22006371
Source
Medline
License
Unknown

Abstract

We introduce Twist1 and MAML1 as new molecular markers of advanced tumor, which determine the characteristics and aggressive behavior of ESCC. Along with the emerging evidence of their role in different cellular processes and aberrations in various cancers, they are suggested as potentially interesting therapeutic targets to reverse a broad spectrum of functional aberrations that promote ESCC development.

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