Affordable Access

Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer.

Authors
  • Mathioudaki, Konstantina
  • Scorilas, Andreas
  • Papadokostopoulou, Alexandra
  • Xynopoulos, Dimitrios
  • Arnogianaki, Niki
  • Agnanti, Niki
  • Talieri, Maroulio
Type
Published Article
Journal
Biological chemistry
Publication Date
Sep 01, 2004
Volume
385
Issue
9
Pages
779–783
Identifiers
PMID: 15493871
Source
Medline
License
Unknown

Abstract

Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes' stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.

Report this publication

Statistics

Seen <100 times