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Expression of alpha smooth muscle actin in living donor liver transplant recipients.

Authors
  • Hirabaru, Masataka
  • Mochizuki, Kyoko
  • Takatsuki, Mitsuhisa
  • Soyama, Akihiko
  • Kosaka, Taiichiro
  • Kuroki, Tamotsu
  • Shimokawa, Isao
  • Eguchi, Susumu
Type
Published Article
Journal
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Co
Publication Date
Jun 14, 2014
Volume
20
Issue
22
Pages
7067–7074
Identifiers
DOI: 10.3748/wjg.v20.i22.7067
PMID: 24966580
Source
Medline
Keywords
License
Unknown

Abstract

Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patients who underwent living donor liver transplantation and ceased immunosuppressant therapy. The number of α-SMA-positive cells in the specimens obtained by liver biopsy from these two patients showed a three-fold increase compared with the number from four transplanted pediatric patients who were continuing immunosuppressant therapy. In addition, the α-SMA-positive area evaluated using the WinRooF image processing software program continued to increase over time in three adult transplanted patients with liver fibrosis, and the α-SMA-positive area was increasing even during the pre-fibrotic stage in these adult cases, according to a retrospective review. Therefore, α-SMA could be a useful marker for the detection of early stage fibrosis.

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