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Expression of ADAMTS 1-4-8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester.

Authors
  • Tatar, Musa1
  • Tufekci, Kıymet Kubra2
  • Uslu, Sema3
  • Öner, Jale4
  • 1 Department of Histology and Embryology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu, Turkey. , (Turkey)
  • 2 Department of Histology and Embryology, Faculty of Medicine, Kastamonu University, Kastamonu, Turkey. , (Turkey)
  • 3 Department of Histology and Embryology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey. , (Turkey)
  • 4 Department of Basic Sciences of Histology and Embryology, Faculty of Dentistry, Burdur Mehmet Akif Ersoy University, Burdur, Turkey. , (Turkey)
Type
Published Article
Journal
Anatomia Histologia Embryologia
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jul 01, 2023
Volume
52
Issue
4
Pages
619–626
Identifiers
DOI: 10.1111/ahe.12922
PMID: 37014320
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A Disintegrin and Metalloprotease Domains with Thrombospondins Motifs (ADAMTS), proteinases responsible for the destruction of extracellular matrix structures, have essential roles in the physiological and pathological processes of the female reproductive system, which is a dynamic structure. This study aimed to evaluate the immunoreactivity of placental growth factor (PLGF) and ADAMTS' (1, -4, and -8) in the ovary and oviduct during pregnancy in the first trimester. Our findings suggest a predominant role of ADAMTS-4 and ADAMTS-8 as proteoglycan-degrading enzymes from the ADAMTS-1 in the first trimester. As an angiogenic factor, PLGF showed more immunoreactivity than ADAMTS-1 in the ovary. This study provides the first evidence that ADAMTS-4 and ADAMTS-8 are more expressed in ovarian cells and follicles at different developmental stages during the first trimester of pregnancy than ADAMTS-1. Consequently, we suggest that ADAMTSs and PLGF act together and may exert specific effects on the formation, stabilisation, and function (or a combination thereof) of the matrix surrounding and protecting the follicles. © 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.

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