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Exposure to the Harmful Algal Bloom (HAB) Toxin Microcystin-LR (MC-LR) Prolongs and Increases Severity of Dextran Sulfate Sodium (DSS)-Induced Colitis

Authors
  • robin, su c.
  • blomquist, thomas m.
  • kleinhenz, andrew l.
  • khalaf, fatimah k.
  • dube, prabhatchandra
  • lad, apurva
  • breidenbach, joshua d.
  • mohammed, chrysan j.
  • zhang, shungang
  • baum, caitlin e.
  • malhotra, deepak
  • kennedy, david j.
  • haller, steven t.
Publication Date
Jun 25, 2019
Identifiers
DOI: 10.3390/toxins11060371
OAI: oai:mdpi.com:/2072-6651/11/6/371/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

, CD40, MCP-1) and the pro-fibrotic marker, PAI-1, as compared to DSS-only ingestion. These findings demonstrate that MC-LR exposure not only prolongs, but also worsens the severity of pre-existing colitis, strengthening evidence of MC-LR as an under-recognized environmental toxin in vulnerable populations, such as those with IBD.

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