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Exploring the magic bullets to identify Achilles' heel in SARS-CoV-2: Delving deeper into the sea of possible therapeutic options in Covid-19 disease: An update.

Authors
  • Thakur, Shikha1
  • Mayank,2
  • Sarkar, Bibekananda3
  • Ansari, Arshad J4
  • Khandelwal, Akanksha5
  • Arya, Anil6
  • Poduri, Ramarao7
  • Joshi, Gaurav8
  • 1 Department of Pharmaceutical Sciences and Natural Products, School of Health Science, Central University of Punjab, Bathinda 151 001, India. , (India)
  • 2 Shobhaben Pratapbhai Patel - School of Pharmacy & Technology Management, SVKM's NMIMS University, Vile Parle, Mumbai 400056, India. , (India)
  • 3 B.S.S. College, Supaul. B.N Mandal University, Madhepura, Bihar 852131, India. , (India)
  • 4 School of Chemical Sciences and Pharmacy, Central University of Rajasthan, NH-8, Bandar Sindri, Ajmer 305817, Rajasthan, India. , (India)
  • 5 Department of Biochemistry and Microbial Sciences, Central University of Punjab, Bathinda, Punjab, India. , (India)
  • 6 Department of Physics, Central University of Punjab, Bathinda 151 001, India. Electronic address: [email protected] , (India)
  • 7 Department of Pharmaceutical Sciences and Natural Products, School of Health Science, Central University of Punjab, Bathinda 151 001, India. Electronic address: [email protected] , (India)
  • 8 Department of Pharmaceutical Sciences and Natural Products, School of Health Science, Central University of Punjab, Bathinda 151 001, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Date
Nov 27, 2020
Volume
147
Pages
111887–111887
Identifiers
DOI: 10.1016/j.fct.2020.111887
PMID: 33253764
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The symptoms associated with Covid-19 caused by SARS-CoV-2 in severe conditions can cause multiple organ failure and fatality via a plethora of mechanisms, and it is essential to discover the efficacious and safe drug. For this, a successful strategy is to inhibit in different stages of the SARS-CoV-2 life cycle and host cell reactions. The current review briefly put forth the summary of the SARS-CoV-2 pandemic and highlight the critical areas of understanding in genomics, proteomics, medicinal chemistry, and natural products derived drug discovery. The review further extends to briefly put forth the updates in the drug testing system, biologics, biophysics, and their advances concerning SARS-CoV-2. The salient features include information on SARS-CoV-2 morphology, genomic characterization, and pathophysiology along with important protein targets and how they influence the drug design and development against SARS-CoV-2 and a concerted and integrated approach to target these stages. The review also gives the status of drug design and discovery to identify the drugs acting on critical targets in SARS-CoV-2 and host reactions to treat Covid-19. Copyright © 2020 Elsevier Ltd. All rights reserved.

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