Exploration of auditory P50 gating in schizophrenia by way of difference waves

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Exploration of auditory P50 gating in schizophrenia by way of difference waves

Publisher
BioMed Central
Publication Date
Jan 28, 2006
Source
PMC
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Unknown

Abstract

1744-9081-2-6.fm ral ss BioMed CentBehavioral and Brain Functions Open AcceShort paper Exploration of auditory P50 gating in schizophrenia by way of difference waves Sidse M Arnfred* Address: Experiments performed at the Department of Psychiatry, Bispebjerg Hospital, University Hospital of Copenhagen, Bispebjerg Bakke 23, DK-2400 København NV, Denmark Email: Sidse M Arnfred* - [email protected] * Corresponding author Abstract Electroencephalographic measures of information processing encompass both mid-latency evoked potentials like the pre-attentive auditory P50 potential and a host of later more cognitive components like P300 and N400. Difference waves have mostly been employed in studies of later event related potentials but here this method along with low frequency filtering is applied exploratory on auditory P50 gating data, previously analyzed in the standard format (reported in Am J Psychiatry 2003, 160:2236-8). The exploration was motivated by the observation during visual peak detection that the AEP waveform was different in the patient group, although this was not reflected by the peak measures. The sample included un-medicated schizophrenia spectrum patients (n = 17) and healthy controls (n = 24). The patients had an attenuated difference P50. This attenuation was primarily seen in the sub- sample of patients with severe negative symptoms. The difference attenuation was due to low amplitude at the first stimulus. This suggests an abnormality in readiness more than an abnormality in gating in the patient group. Introduction The deficiency in auditory P50 gating reported in numer- ous studies of schizophrenic patients has been one of the experimental findings that have supported the theory of defect sensory gating in schizophrenia [1]. P50 gating is the relative amplitude reduction of auditory evoked potential (AEP) P50 from the first stimulus (S1) to the sec- ond stimulus (S2). P50 is the second positive component of the mid-latency AEP; a scalp electroen

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