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Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes.

Authors
  • Farrer, Nicola J1
  • Griffith, Darren M2
  • 1 Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • 2 Department of Chemistry, RCSI, 123 St. Stephens Green, Dublin 2, Ireland; SSPC, Synthesis and Solid State Pharmaceutical Centre, Ireland. Electronic address: [email protected] , (Ireland)
Type
Published Article
Journal
Current opinion in chemical biology
Publication Date
Apr 01, 2020
Volume
55
Pages
59–68
Identifiers
DOI: 10.1016/j.cbpa.2019.12.001
PMID: 31945705
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It represents a powerful and versatile tool, which can be exploited to develop novel Pt-based anticancer drugs and to better understand the biological effects of Pt-based anticancer drugs at a cellular level. Innovative azide-alkyne cycloaddition-based approaches are being used to functionalise Pt-based complexes with biomolecules to enhance tumour targeting. Valuable information in relation to the mechanisms of action and resistance of Pt-based drugs is also being revealed through click-based detection, isolation and tracking of Pt drug surrogates in biological and cellular environments. Although less well-explored, inorganic Pt-click reactions enable synthesis of novel (potentially multimetallic) Pt complexes and provide plausible routes to introduce functional groups and monitoring Pt-azido drug localisation. Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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