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Exploitation of in silico potential in prediction, validation and elucidation of mechanism of anti-angiogenesis by novel compounds: comparative correlation between wet lab and in silico data.

Authors
  • Arif, Jamal M
  • Siddiqui, M Haris
  • Akhtar, Salman
  • Al-Sagair, Othman A
Type
Published Article
Journal
International journal of bioinformatics research and applications
Publication Date
Jan 01, 2013
Volume
9
Issue
4
Pages
336–348
Identifiers
DOI: 10.1504/IJBRA.2013.054697
PMID: 23797993
Source
Medline
License
Unknown

Abstract

This study describes in silico validation of the wet lab data from aeroplysinin-1, curcumin and halofuginone using Autodock Tools 4.0. The inhibition patterns of the vascular endothelial cell differentiation and capillary tube formation mediated by anti-angiogenic growth factors from these test compounds were found quite comparable with the in silico results using angiogenic targets (EFGR, bFGF and VEGFR-1). Successful validation of the wet lab results of the selected angiogenic targets by in silico method has led to exploit the hidden potential of in silico tools in preliminary screening of the unknown compounds for anti-angiogenic potential in a cost-effective manner.

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