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[An expert system as an aid to the validation of results of the antibiogram. Feasibility study based on the example of Staphylococcus aureus].

Authors
  • Comby, S
  • Flandrois, J P
  • Pave, A
Type
Published Article
Journal
Pathologie Biologie
Publisher
Elsevier
Publication Date
May 01, 1988
Volume
36
Issue
5
Pages
381–385
Identifiers
PMID: 3043332
Source
Medline
License
Unknown

Abstract

A model of expert system using Prolog language was developed, to verify the coherence of the results of the antibiotic sensitivity test. Biological knowledge was formalized in three different ways: a credibility coefficient based on epidemiological data is assigned to known observed resistance; co-existent resistances are described with lists of "implicit" resistances, reflecting phenotypes commonly observed within some antibiotic groups; every single or "implicit" resistance is connected to a "gregarius" status, expressing the plasmidic nature of resistance. Applied to Staphylococcus aureus, the expert system is able to detect the inconsistencies of the antibiotic sensitivity test and to identify required knowledges. It therefore allows phenotypic interpretation of results.

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