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Experimentally induced susceptibility to audiogenic seizure.

Authors
  • Chung, S H
  • Johnson, M S
Type
Published Article
Journal
Experimental neurology
Publication Date
Oct 01, 1983
Volume
82
Issue
1
Pages
89–107
Identifiers
PMID: 6628617
Source
Medline
License
Unknown

Abstract

By injecting metal ions and pyridoxal-5'-phosphate, we made the normal mouse prone to sound-induced epilepsy. We showed that the levels of glutamate and aspartate in its inferior colliculus were elevated and the concentration of gamma-aminobutyrate was lowered. The time course of audiogenic susceptibility after the treatment was closely mirrored by changes in the concentrations of glutamate, aspartate, and gamma-aminobutyrate in the inferior colliculus.

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