Experimentally induced susceptibility to audiogenic seizure.
- Published Article
- Publication Date
Oct 01, 1983
By injecting metal ions and pyridoxal-5'-phosphate, we made the normal mouse prone to sound-induced epilepsy. We showed that the levels of glutamate and aspartate in its inferior colliculus were elevated and the concentration of gamma-aminobutyrate was lowered. The time course of audiogenic susceptibility after the treatment was closely mirrored by changes in the concentrations of glutamate, aspartate, and gamma-aminobutyrate in the inferior colliculus.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6628617