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Experimental in vivo imaging of the cranial perineural lymphatic pathway.

Authors
Type
Published Article
Journal
AJNR. American journal of neuroradiology
Publication Date
Volume
5
Issue
5
Pages
539–545
Identifiers
PMID: 6435420
Source
Medline

Abstract

After intraventricular injection of 99mTc antimony sulfide in rabbits (n = 12) and cats (n = 14), radiolabeled colloid was imaged passing into the nasal mucosa and subsequently into the cervical lymph nodes. The cervical lymph nodes accounted for about 12% of the injected dose in rabbits sacrificed at 22-24 hr after injection and about 5% of the injected dose in cats sacrificed at 5-6 hr after injection. In both animals this represented at least one-third of the cerebrospinal fluid colloid clearance. This technique is applicable to in vivo imaging studies of the perineural lymphatic pathway for cerebrospinal fluid absorption in primates and, with modifications, in human subjects.

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