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Experimental transmission of macaque AIDS by means of inoculation of macaque lymphoma tissue.

Authors
  • Letvin, N L
  • Aldrich, W R
  • King, N W
  • Blake, B J
  • Daniel, M D
  • Hunt, R D
Type
Published Article
Journal
Lancet (London, England)
Publication Date
Sep 10, 1983
Volume
2
Issue
8350
Pages
599–602
Identifiers
PMID: 6136748
Source
Medline
License
Unknown

Abstract

Acquired immuno-deficiency syndrome (AIDS) of macaques, an animal model for human AIDS, was transmitted to previously healthy macaque monkeys by means of inoculation of either tissue or a cell-free filtrate of a macaque lymphoma. The recipients showed evidence of profound lymphocyte dysfunction or died with infections from such opportunistic agents as Candida albicans, Cryptosporidium, and cytomegalovirus.

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