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Experimental retinal branch vein occlusion in the monkey. Histopathological and ultrastructural studies.

Authors
  • Hockley, D J
  • Tripathi, R C
  • Ashton, N
Type
Published Article
Journal
Transactions of the ophthalmological societies of the United Kingdom
Publication Date
Jul 01, 1976
Volume
96
Issue
2
Pages
202–209
Identifiers
PMID: 827828
Source
Medline
License
Unknown

Abstract

Light and electron microscopical studies of monkey retinae after experimental branch vein occlusion by argon laser reveal that the immediate reaction in the corresponding region is one of capillary engorgement and dilatation followed by oedema (intra- and extracellular), and plasma leakage as shown by intravenous injection of horseradish peroxidase. Vascular stasis is characterized by packing of erythrocytes in the capillary lumen, early thrombus formation, and focal haemorrhages. Progressive degenerative changes in the endothelium and pericytes are seen in specimens taken a few hours to a few days after occlusion; within 3 to 4 weeks many vessels in the occluded region are reduced to basement membrane "ghosts" and the lumen and the cellular lodges of some vessels are subsequently invaded by proliferating glia, thus producing permanent capillary closure.

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