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Experimental Modeling of Sepsis

Authors
  • Cherkasova, M. N.1
  • 1 Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia , Moscow (Russia)
Type
Published Article
Journal
Biology Bulletin Reviews
Publisher
Pleiades Publishing
Publication Date
Dec 01, 2021
Volume
11
Issue
Suppl 1
Pages
65–77
Identifiers
DOI: 10.1134/S2079086421070033
Source
Springer Nature
Keywords
Disciplines
  • Article
License
Yellow

Abstract

AbstractFour variants of experimental models of sepsis are discussed: injection, surgical, burn, and models of pneumonia with transition to sepsis. The positive and negative aspects of each of them are analyzed. It is noted that the optimal choice of animals is the most important condition for successful sepsis modeling. Some aspects of anatomy, physiology, and immunology characteristic of a particular mammalian species are considered. If the existing differences in reactions are taken into account, it is possible to note complexes of signs that are similar or identical in different representatives of animals in sepsis. Although limitations that apply to each sepsis model, it is advisable to use different models on different animal species. Comparison and contrast of the results of experiments is extremely important to clarify the pathogenetic criteria of sepsis.

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