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Experimental latent and recrudescent bovine herpesvirus-1 infections in calves.

Authors
Type
Published Article
Journal
American Journal of Veterinary Research
0002-9645
Publisher
American Veterinary Medical Association
Publication Date
Volume
44
Issue
2
Pages
309–313
Identifiers
PMID: 6299146
Source
Medline
License
Unknown

Abstract

Latent bovine herpesvirus-1 (BHV-1) infection was established in 6 calves and was demonstrated by reinduction of virus shedding after administration of corticosteroids. Latently infected calves failed to transmit BHV-1 during 4 weeks' contact with sentinel calves. Infected calves were killed and necropsied during latency or induced recrudescence. The BHV-1 DNA was demonstrated intranuclearly in trigeminal ganglion neurons by in situ hybridization. The BHV-1 antigen was demonstrated by immunofluorescence in trigeminal ganglion neurons during recrudescence. By electron microscopy, changes in the appearance of the Nissl bodies and a high frequency of nuclear bodies were observed in trigeminal ganglion neurons.

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