A novel hospital bed integrated ventilation and cleaning unit (HBIVCU) was developed to reduce the exposure of medical staff, visitors, etc. to coughed air from a sick patient. The performance efficiency of the unit was studied in a full-scale mock-up of a hospital room with two beds with patients and a doctor. Four HBIVCUs were placed along the two sides of the two beds. The room was ventilated by mixing air distribution (ceiling installed supply air terminals) at room air temperature of 22 °C. The coughing patient and the second exposed patient were simulated by two heated dummies with simplified geometry. Thermal manikin with realistic body shape and surface temperature distribution was used to mimic the doctor standing beside the bed of the coughing patient. The doctor and the coughing patient were facing each other. The coughing dummy was equipped with a cough generator. The cough produced consisted of 100% CO2. The performance of the developed unit at background ventilation rates equivalent to 3 h<sup>-1</sup>and 6 h<sup>-1</sup> was evaluated by measuring the excess CO2 concentration at the mouth of the doctor and at the mouth of the exposed patient. When the novel method was not used, the measured Peak Concentration Level of CO2 was 10288 ppm and 5518 ppm for the doctor and for the exposed patient respectively. With the HBIVCUs installed and operational no significant increase in the CO2 concentration above the background room level was measured. The performance of the unit at 3 and 6 h<sup>-1</sup> was the same suggesting possible energy savings when operated at the lower background ventilation rate.