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Experimental disease in young chickens induced by a Mycobacterium paratuberculosis isolate from a patient with Crohn's disease.

Authors
  • Van Kruiningen, H J
  • Ruiz, B
  • Gumprecht, L
Type
Published Article
Journal
Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire
Publication Date
Apr 01, 1991
Volume
55
Issue
2
Pages
199–202
Identifiers
PMID: 1832080
Source
Medline
License
Unknown

Abstract

The susceptibility of young chickens to infection with an isolate of Mycobacterium paratuberculosis which had been recovered from diseased tissues of a patient with Crohn's disease was determined. Two-week-old Leghorn-Cochin chicks were inoculated with strain Linda. Six birds received 10(7) organisms orally, six intraperitoneally, and five intracardially. Six uninoculated birds served as contact controls. Birds from each group were necropsied at two-week intervals. Focal granulomatous lesions occurred in two of six chickens which were inoculated orally, in six of six inoculated intraperitoneally, in three of five inoculated intracardially, but in none of six controls. Of the 11 birds with lesions, acid-fast bacilli were demonstrated in five. Immunoperoxidase reactivity paralleled the presence of acid-fast bacilli.

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