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[Experimental diarrhea in mice induced by oral infection with an enterotoxigenic strain of E. coli].

Authors
Type
Published Article
Journal
Biulleten' eksperimental'noĭ biologii i meditsiny
Publication Date
Volume
100
Issue
9
Pages
371–373
Identifiers
PMID: 3899214
Source
Medline
License
Unknown

Abstract

It has been shown in experiments on adult random-bred and BALB/c Sto mice that oral infection with human strain of E. coli N-10407 induces enterocolitis characterized by marked diarrheal syndrome but without lethal outcome. The action of the strain not colonizing the intestinal mucosa of mice may be accounted for by a weak cytopathic effect of the infecting microorganism and its toxin. The data obtained indicate that adult mice may serve as a convenient model for investigation of colibacillary diarrhea induced by enterotoxigenic strain of E. coli, BALB/c Sto mice being a more sensitive model than random-bred animals.

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