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Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant.

Authors
  • Park, Seon-Kyung1
  • Seol, Hwi-Soo2
  • Park, Hee-Jin1
  • Kim, Yoon-Seob1
  • Ryu, Seung-Hun3
  • Kim, Jaehoon3
  • Kim, Suejin3
  • Lee, Jong-Hyeon2
  • Kwon, Jung-Hwan1
  • 1 Division of Environmental Science and Ecological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, Korea. , (North Korea)
  • 2 EH R&C, Environmental Research Center, 410 Jeongseojin-ro, Seo-gu, Incheon, Korea. , (North Korea)
  • 3 Humidifier Disinfectant Health Center, National Institute of Environmental Research, 42 Hwangyong-ro, Seo-gu, Incheon, Korea. , (North Korea)
Type
Published Article
Journal
Environmental analysis, health and toxicology
Publication Date
Jun 01, 2020
Volume
35
Issue
2
Identifiers
DOI: 10.5620/eaht.e2020008
PMID: 32600006
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A mixture of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) had been used as an active ingredient in humidifier disinfectants (HDs). Owing to its high reactivity, the atmospheric concentration of CMIT/MIT, following its use in HD, would be lower than expected assuming that it is removed by ventilation only. In order to evaluate the exposure concentration of CMIT/MIT used as an HD, room-scale chamber studies were conducted under plausible use of three different HD doses at air change rates (ACR) of 0.3, 0.5, and 1.0 h-1. Atmospheric CMIT/MIT was sampled using two serial impingers containing deionized water after the attainment of steady state. Water samples in which CMIT/MIT was dissolved were concentrated using a cosolvent evaporation method with efficiencies of 35.5 and 77.9% for CMIT and MIT, respectively. The estimated air concentration, assuming that all the CMIT/MIT is absorbed in deionized water, increased linearly with increasing emission rate, but was independent of the ACR. This indicates that the removal rate of CMIT/MIT via chemical reactions is more than the removal rate by ventilation. Further investigations on homogeneous and heterogeneous chemical reactions of CMIT/MIT under ambient conditions are necessary to understand the actual exposure concentration of the mixture in HD.

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