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Experiences of specific IgE in asthma due to diisocyanates.

Authors
  • Keskinen, H
  • Tupasela, O
  • Tiikkainen, U
  • Nordman, H
Type
Published Article
Journal
Clinical allergy
Publication Date
Nov 01, 1988
Volume
18
Issue
6
Pages
597–604
Identifiers
PMID: 2854010
Source
Medline
License
Unknown

Abstract

The specific IgE antibodies were studied with the Phadebas RAST technique in 35 patients with asthma due to diisocyanates. Two had been sensitized to toluene diisocyanate (TDI), 17 to methylene diisocyanate (MDI) and 16 to hexamethylene diisocyanate (HDI). In each case the diagnosis was confirmed with a bronchial provocation test (BPT). The asthmatic reaction was immediate in 17 cases, of which three had also a late reaction (dual). Eighteen patients reacted only with a late reaction. Seven (20%) had specific IgE to diisocyanates. All RAST-positive patients had an immediate asthmatic reaction. None of the late reactors and referents had positive RASTs. RAST inhibition tests with 94-100% inhibition confirmed the specificity of the method. There was cross-reactivity between different diisocyanates, however. The patients with positive RAST to diisocyanates had a higher level of total IgE than the RAST negative group and the referents.

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