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Experience of recombinant activated factor VII usage during surgery in patients with haemophilia with inhibitors.

Authors
  • Polyanskaya, T
  • Zorenko, V
  • Karpov, E
  • Sampiev, M
  • Mishin, G
  • Vasiliev, D
Type
Published Article
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
Publication Date
Nov 01, 2012
Volume
18
Issue
6
Pages
997–1002
Identifiers
DOI: 10.1111/j.1365-2516.2012.02866.x
PMID: 22672066
Source
Medline
License
Unknown

Abstract

Inhibitor development is one of the most challenging complications of haemophilia management. Haemostatic control in patients with haemophilia with inhibitors can be difficult, and is especially risky in those undergoing surgical interventions. Most haemophilia patients with inhibitors suffer from chronic joint disease requiring surgical correction due to recurrent bleeding episodes. The aim of this study was to assess the use of recombinant activated factor VII (rFVIIa) as haemostatic therapy during orthopaedic surgery in haemophilia patients with inhibitors. A series of case reports was retrospectively collected to describe clinical experience of rFVIIa use in inhibitor patients undergoing a range of orthopaedic surgical procedures at a single centre. All surgeries were performed using standard methods. All patients received rFVIIa at a starting dose of 120 μg kg(-1) with the subsequent regimens depending on the type of surgery. rFVIIa provided effective haemostasis in 23 patients with haemophilia A and inhibitors (15 with high inhibitor titres) undergoing orthopaedic surgery. The majority (70%) of surgical procedures were major (joint and extra-articular surgery). The doses and intervals of rFVIIa treatment used varied depending on the severity of bleeding, and the type (major or minor) or site of surgery. In all cases, administration of rFVIIa achieved good haemostasis. In all 23 patients with haemophilia with inhibitors, rFVIIa treatment in orthopaedic interventions proved to be an efficient haemostatic agent, providing effective intra-operative and postoperative haemostasis.

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