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Expedient synthesis of tetrasubstituted pyrroles via a copper-catalyzed cascade inter-/intramolecular cyclization of 1,3-enynes carry a nitro group with amines.

Authors
Type
Published Article
Journal
Organic & Biomolecular Chemistry
1477-0539
Publisher
The Royal Society of Chemistry
Publication Date
Volume
13
Issue
9
Pages
2786–2792
Identifiers
DOI: 10.1039/c4ob02508c
PMID: 25604620
Source
Medline
License
Unknown

Abstract

Various tetrasubstituted pyrroles/pyrazoles have been prepared from nitro-substituted 1,3-enynes with aromatic amines/hydrazines via a copper-catalyzed cascade aza-Michael addition, cyclization and aromatization at room temperature. This protocol is also effective for the synthesis of tetrasubstituted pyrazoles in high yields.

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