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An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization

Authors
Type
Published Article
Journal
Tetrahedron Letters
Publisher
Elsevier
Publication Date
Jun 13, 2015
Volume
56
Issue
23
Identifiers
DOI: 10.1016/j.tetlet.2015.01.074
PMID: 26120216
PMCID: PMC4477708
Source
CCHF
License
Green

Abstract

A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C–H functionalization.

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