An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization
- Authors
- Type
- Published Article
- Journal
- Tetrahedron Letters
- Publisher
- Elsevier
- Publication Date
- Jun 13, 2015
- Volume
- 56
- Issue
- 23
- Identifiers
- DOI: 10.1016/j.tetlet.2015.01.074
- PMID: 26120216
- PMCID: PMC4477708
- Source
- CCHF
- License
- Green
Abstract
A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C–H functionalization.