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Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration

Authors
  • Fan, Lei1, 2
  • Guan, Pengfei3
  • Xiao, Cairong1
  • Wen, Huiquan4
  • Wang, Qiyou3
  • Liu, Can5
  • Luo, Yian6
  • Ma, Limin7
  • Tan, Guoxin6
  • Yu, Peng1
  • Zhou, Lei1, 6
  • Ning, Chengyun1
  • 1 School of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510641, China
  • 2 Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China
  • 3 Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China
  • 4 Department of Radiology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China
  • 5 Department of Spine Surgery, the First Hospital of Zhejiang University, Hangzhou, 310003, China
  • 6 School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, China
  • 7 Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China
Type
Published Article
Journal
Bioactive Materials
Publisher
KeAi Publishing
Publication Date
Feb 15, 2021
Volume
6
Issue
9
Pages
2754–2766
Identifiers
DOI: 10.1016/j.bioactmat.2021.02.005
PMID: 33665507
PMCID: PMC7897935
Source
PubMed Central
Keywords
License
Unknown

Abstract

• The implanted biomaterials as foreign substances trigger a cascade of immune responses. • BMSC-derived exosomes with immunomodulatory were suitable for bioactive coating to exert osteoimmunomodulation effect. • Exosome-functionalized SPEEK can modulate macrophages M2 polarization via NF‐κB pathway. • Exosome-functionalized SPEEK with osteoimmunomodulation properties can promote osseointegration.

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