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Exosomal noncoding RNAs in colorectal cancer.

Authors
  • Wu, Qingbin1
  • Liu, Wenrong2
  • Wang, Jin3
  • Zhu, Lei4
  • Wang, Ziqiang5
  • Peng, Yong6
  • 1 Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] , (China)
  • 2 Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] , (China)
  • 3 Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] , (China)
  • 4 Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] , (China)
  • 5 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] , (China)
  • 6 Laboratory of Molecular Oncology, State Key Laboratory of Biotherapy and Cancer Center, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Cancer letters
Publication Date
Sep 05, 2020
Identifiers
DOI: 10.1016/j.canlet.2020.08.037
PMID: 32898600
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the behavior of the recipient cells. Increasing evidence has demonstrated that exosomal ncRNAs in blood exhibit distinct expression patterns among CRC patients with or without metastasis, and healthy controls. Moreover, exosomal ncRNAs can participate in the regulation of tumor microenvironment, the establishment of pre-metastatic niches, and the induction of drug resistance via cell-to-cell communication. Intriguingly, exosomal ncRNAs have the potential to serve as biomarkers for diagnosis, prognostic prediction, and therapeutic response monitoring of patients with CRC. In this review, we summarize the emerging functions of exosomal ncRNAs during CRC development and also discuss their potential clinical application in patients with CRC. Copyright © 2020. Published by Elsevier B.V.

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