Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Authors

• Flannick, Jason^{1, 2, 3, 4}
• Mercader, Josep M.^{1, 4, 5, 6, 7}
• Fuchsberger, Christian^{8, 9, 10}
• Udler, Miriam S.^{1, 4, 5, 6, 7}
• Mahajan, Anubha^{11, 12}
• Wessel, Jennifer^{13, 14, 15}
• Teslovich, Tanya M.¹⁶
• Caulkins, Lizz^{1, 4}
• Koesterer, Ryan^{1, 4}
• Barajas-Olmos, Francisco¹⁷
• Blackwell, Thomas W.^{8, 10}
• Boerwinkle, Eric^{18, 19}
• Brody, Jennifer A.²⁰
• Centeno-Cruz, Federico¹⁷
• Chen, Ling^{6, 7}
• Chen, Siying^{8, 10}
• Contreras-Cubas, Cecilia¹⁷
• Córdova, Emilio¹⁷
• Correa, Adolfo²¹
• Cortes, Maria²²
• DeFronzo, Ralph A.²³
• Dolan, Lawrence²⁴
• Drews, Kimberly L.²⁵
• Elliott, Amanda^{1, 4, 6, 7}
• Floyd, James S.²⁶
• Gabriel, Stacey²²
• Garay-Sevilla, Maria Eugenia^{27, 28}
• García-Ortiz, Humberto¹⁷
• Gross, Myron²⁹
• Han, Sohee³⁰
• Heard-Costa, Nancy L.^{31, 32}
• Jackson, Anne U.^{8, 10}
• Jørgensen, Marit E.^{33, 34, 35}
• Kang, Hyun Min^{8, 10}
• Kelsey, Megan²⁵
• Kim, Bong-Jo³⁰
• Koistinen, Heikki A.^{36, 37, 38}
• Kuusisto, Johanna^{39, 40}
• Leader, Joseph B.⁴¹
• Linneberg, Allan^{42, 43, 44}
• Liu, Ching-Ti⁴⁵
• Liu, Jianjun^{46, 47, 48}
• Lyssenko, Valeriya^{49, 50}
• Manning, Alisa K.^{7, 51}
• Marcketta, Anthony¹⁶
• Malacara-Hernandez, Juan Manuel^{27, 28}
• Martínez-Hernández, Angélica¹⁷
• Matsuo, Karen^{8, 10}
• Mayer-Davis, Elizabeth⁵²
• Mendoza-Caamal, Elvia¹⁷
• Mohlke, Karen L.⁵³
• Morrison, Alanna C.¹⁸
• Ndungu, Anne¹¹
• Ng, Maggie C. Y.^{54, 55, 56}
• O’Dushlaine, Colm¹⁶
• Payne, Anthony J.¹¹
• Pihoker, Catherine⁵⁷
• Post, Wendy S.⁵⁸
• Preuss, Michael⁵⁹
• Psaty, Bruce M.^{60, 61, 62, 63, 64}
• Vasan, Ramachandran S.^{32, 65}
• Rayner, N. William^{11, 12, 66}
• Reiner, Alexander P.⁶³
• Revilla-Monsalve, Cristina⁶⁷
• Robertson, Neil R.^{11, 12}
• Santoro, Nicola⁶⁸
• Schurmann, Claudia⁵⁹
• So, Wing Yee^{69, 70, 71}
• Soberón, Xavier¹⁷
• Stringham, Heather M.^{8, 10}
• Strom, Tim M.^{72, 73}
• Tam, Claudia H. T.^{69, 70, 71}
• Thameem, Farook⁷⁴
• Tomlinson, Brian⁶⁹
• Torres, Jason M.¹¹
• Tracy, Russell P.^{75, 76}
• van Dam, Rob M.^{47, 48, 77}
• Vujkovic, Marijana⁷⁸
• Wang, Shuai⁴⁵
• Welch, Ryan P.^{8, 10}
• Witte, Daniel R.^{79, 80}
• Wong, Tien-Yin^{81, 82, 83}
• Atzmon, Gil^{84, 85, 86}
• Barzilai, Nir^{84, 86}
• Blangero, John^{87, 88}
• Bonnycastle, Lori L.⁸⁹
• Bowden, Donald W.^{54, 55, 56}
• Chambers, John C.^{90, 91, 92}
• Chan, Edmund⁴⁷
• Cheng, Ching-Yu⁹³
• Cho, Yoon Shin⁹⁴
• Collins, Francis S.⁸⁹
• de Vries, Paul S.¹⁸
• Duggirala, Ravindranath^{87, 88}
• Glaser, Benjamin⁹⁵
• Gonzalez, Clicerio⁹⁶
• Gonzalez, Ma Elena⁹⁷
• Groop, Leif^{49, 98}
• Kooner, Jaspal Singh⁹⁹
• Kwak, Soo Heon¹⁰⁰
• Laakso, Markku^{39, 40}
• Lehman, Donna M.²³
• Nilsson, Peter¹⁰¹
• Spector, Timothy D.¹⁰²
• Tai, E. Shyong^{47, 48, 82}
• Tuomi, Tiinamaija^{98, 103, 104, 105}
• Tuomilehto, Jaakko^{106, 107, 108, 109}
• Wilson, James G.¹¹⁰
• Aguilar-Salinas, Carlos A.¹¹¹
• Bottinger, Erwin⁵⁹
• Burke, Brian²⁵
• Carey, David J.⁴¹
• Chan, Juliana C. N.^{69, 70, 71}
• Dupuis, Josée^{32, 45}
• Frossard, Philippe¹¹²
• Heckbert, Susan R.^{60, 63}
• Hwang, Mi Yeong³⁰
• Kim, Young Jin³⁰
• Kirchner, H. Lester⁴¹
• Lee, Jong-Young¹¹³
• Lee, Juyoung³⁰
• Loos, Ruth J. F.^{59, 114}
• Ma, Ronald C. W.^{69, 70, 71}
• Morris, Andrew D.¹¹⁵
• O’Donnell, Christopher J.^{3, 116, 117, 118}
• Palmer, Colin N. A.¹¹⁹
• Pankow, James¹²⁰
• Park, Kyong Soo^{99, 121, 122}
• Rasheed, Asif¹¹²
• Saleheen, Danish^{78, 112}
• Sim, Xueling⁴⁸
• Small, Kerrin S.¹⁰²
• Teo, Yik Ying^{48, 123, 124}
• Haiman, Christopher¹²⁵
• Hanis, Craig L.¹²⁶
• Henderson, Brian E.¹²⁵
• Orozco, Lorena¹⁷
• Tusié-Luna, Teresa^{111, 127}
• Dewey, Frederick E.¹⁶
• Baras, Aris¹⁶
• Gieger, Christian^{128, 129}
• Meitinger, Thomas^{72, 73, 130}
• Strauch, Konstantin^{128, 131}
• Lange, Leslie¹³²
• Grarup, Niels¹³³
• Hansen, Torben^{133, 134}
• Pedersen, Oluf¹³³
• Zeitler, Philip¹³⁵
• Dabelea, Dana¹³⁶
• Abecasis, Goncalo^{8, 10}
• Bell, Graeme I.^{27, 28}
• Cox, Nancy J.¹³⁷
• Seielstad, Mark^{138, 139}
• Sladek, Rob^{140, 141, 142}
• Meigs, James B.^{22, 7, 143}
• Rich, Steve S.¹⁴⁴
• Rotter, Jerome I.^{145, 146, 147}
• Altshuler, David^{1, 4, 6, 7, 148, 149, 150}
• Burtt, Noël P.^{1, 4}
• Scott, Laura J.^{8, 10}
• Morris, Andrew P.^{11, 151}
• Florez, Jose C.^{1, 4, 5, 6, 7, 1}
• McCarthy, Mark I.^{11, 12, 152}
• Boehnke, Michael^{8, 10}
And 144 more

• ¹ Broad Institute, Program in Metabolism, Cambridge, MA, USA , Cambridge (United States)
• ² Boston Children’s Hospital, Division of Genetics and Genomics, Boston, MA, USA , Boston (United States)
• ³ Harvard Medical School, Department of Pediatrics, Boston, MA, USA , Boston (United States)
• ⁴ Broad Institute, Program in Medical & Population Genetics, Cambridge, MA, USA , Cambridge (United States)
• ⁵ Massachusetts General Hospital, Center for Genomic Medicine, Boston, MA, USA , Boston (United States)
• ⁶ Massachusetts General Hospital, Diabetes Research Center (Diabetes Unit), Boston, MA, USA , Boston (United States)
• ⁷ Harvard Medical School, Department of Medicine, Boston, MA, USA , Boston (United States)
• ⁸ University of Michigan, Department of Biostatistics, Ann Arbor, MI, USA , Ann Arbor (United States)
• ⁹ Eurac Research, Institute for Biomedicine, Bolzano, Italy , Bolzano (Italy)
• ¹⁰ University of Michigan, Center for Statistical Genetics, Ann Arbor, MI, USA , Ann Arbor (United States)
• ¹¹ University of Oxford, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford, UK , Oxford (United Kingdom)
• ¹² University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Oxford, UK , Oxford (United Kingdom)
• ¹³ Indiana University, Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, IN, USA , Indianapolis (United States)
• ¹⁴ Indiana University, Department of Medicine, School of Medicine, Indianapolis, IN, USA , Indianapolis (United States)
• ¹⁵ Indiana University, Diabetes Translational Research Center, Indianapolis, IN, USA , Indianapolis (United States)
• ¹⁶ Regeneron Pharmaceuticals, Regeneron Genetics Center, Tarrytown, NY, USA , Tarrytown (United States)
• ¹⁷ Instituto Nacional de Medicina Genómica, Mexico City, Mexico , Mexico City (Mexico)
• ¹⁸ The University of Texas Health Science Center at Houston, Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, Houston, TX, USA , Houston (United States)
• ¹⁹ Baylor College of Medicine, Human Genome Sequencing Center, Houston, TX, USA , Houston (United States)
• ²⁰ University of Washington, Cardiovascular Research Unit, Department of Medicine, Seattle, WA, USA , Seattle (United States)
• ²¹ University of Mississippi Medical Center, Department of Medicine, Jackson, MS, USA , Jackson (United States)
• ²² Broad Institute of MIT and Harvard, Cambridge, MA, USA , Cambridge (United States)
• ²³ University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA , San Antonio (United States)
• ²⁴ Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA , Cincinnati (United States)
• ²⁵ George Washington University, Biostatistics Center, Rockville, MD, USA , Rockville (United States)
• ²⁶ University of Washington, Department of Medicine and Epidemiology, Seattle, WA, USA , Seattle (United States)
• ²⁷ The University of Chicago, Department of Medicine, Chicago, IL, USA , Chicago (United States)
• ²⁸ The University of Chicago, Department of Human Genetics, Chicago, IL, USA , Chicago (United States)
• ²⁹ University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA , Minneapolis (United States)
• ³⁰ Center for Genome Science, National Institute of Health, Division of Genome Research, Chungcheongbuk-do, South Korea , Chungcheongbuk-do (South Korea)
• ³¹ Boston University School of Medicine, Department of Neurology, Boston, MA, USA , Boston (United States)
• ³² National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA , Framingham (United States)
• ³³ Steno Diabetes Center Copenhagen, Gentofte, Denmark , Gentofte (Denmark)
• ³⁴ University of Southern Denmark, National Institute of Public Health, Copenhagen, Denmark , Copenhagen (Denmark)
• ³⁵ University of Greenland, Greenland Centre for Health Research, Nuuk, Greenland , Nuuk (Greenland)
• ³⁶ National Institute for Health and Welfare, Department of Public Health Solutions, Helsinki, Finland , Helsinki (Finland)
• ³⁷ Helsinki University Central Hospital, University of Helsinki and Department of Medicine, Helsinki, Finland , Helsinki (Finland)
• ³⁸ Minerva Foundation Institute for Medical Research, Helsinki, Finland , Helsinki (Finland)
• ³⁹ University of Eastern Finland, Institute of Clinical Medicine, Internal Medicine, Kuopio, Finland , Kuopio (Finland)
• ⁴⁰ Kuopio University Hospital, Department of Medicin, Kuopio, Finland , Kuopio (Finland)
• ⁴¹ Geisinger Health System, Danville, PA, USA , Danville (United States)
• ⁴² University of Copenhagen, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark , Copenhagen (Denmark)
• ⁴³ Bispebjerg and Frederiksberg Hospital, Center for Clinical Research and Prevention, Copenhagen, Denmark , Copenhagen (Denmark)
• ⁴⁴ Rigshospitalet, Department of Clinical Experimental Research, Copenhagen, Denmark , Copenhagen (Denmark)
• ⁴⁵ Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA , Boston (United States)
• ⁴⁶ Agency for Science Technology and Research, Genome Institute of Singapore, Singapore, Singapore , Singapore (Singapore)
• ⁴⁷ National University of Singapore, National University Health System, Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore , Singapore (Singapore)
• ⁴⁸ National University of Singapore, Saw Swee Hock School of Public Health, Singapore, Singapore , Singapore (Singapore)
• ⁴⁹ Lund University Diabetes Centre, Department of Clinical Sciences, Diabetes and Endocrinology, Malmö, Sweden , Malmö (Sweden)
• ⁵⁰ University of Bergen, Department of Clinical Science, Bergen, Norway , Bergen (Norway)
• ⁵¹ Massachusetts General Hospital, Harvard University, Clinical and Translational Epidemiology Unit, Boston, MA, USA , Boston (United States)
• ⁵² University of North Carolina Chapel Hill, Chapel Hill, NC, USA , Chapel Hill (United States)
• ⁵³ University of North Carolina Chapel Hill, Department of Genetics, Chapel Hill, NC, USA , Chapel Hill (United States)
• ⁵⁴ Wake Forest School of Medicine, Center for Diabetes Research, Winston-Salem, NC, USA , Winston-Salem (United States)
• ⁵⁵ Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, NC, USA , Winston-Salem (United States)
• ⁵⁶ Wake Forest School of Medicine, Department of Biochemistry, Winston-Salem, NC, USA , Winston-Salem (United States)
• ⁵⁷ Seattle Children’s Hospital, Seattle, WA, USA , Seattle (United States)
• ⁵⁸ Johns Hopkins University, Division of Cardiology, Department of Medicine, Baltimore, MD, USA , Baltimore (United States)
• ⁵⁹ Mount Sinai School of Medicine, Charles R. Bronfman Institute of Personalized Medicine, New York, NY, USA , New York (United States)
• ⁶⁰ University of Washington, Cardiovascular Health Research Unit, Seattle, WA, USA , Seattle (United States)
• ⁶¹ Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA , Seattle (United States)
• ⁶² University of Washington, Department of Medicine, Seattle, WA, USA , Seattle (United States)
• ⁶³ University of Washington, Department of Epidemiology, Seattle, WA, USA , Seattle (United States)
• ⁶⁴ University of Washington, Department of Health Services, Seattle, WA, USA , Seattle (United States)
• ⁶⁵ Boston University School of Medicine, Preventive Medicine & Epidemiology, Medicine, Boston, MA, USA , Boston (United States)
• ⁶⁶ Wellcome Trust Sanger Institute, Department of Human Genetics, Hinxton, UK , Hinxton (United Kingdom)
• ⁶⁷ Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico , Mexico City (Mexico)
• ⁶⁸ Yale University, Department of Pediatrics, New Haven, CT, USA , New Haven (United States)
• ⁶⁹ The Chinese University of Hong Kong, Department of Medicine and Therapeutics, Hong Kong, China , Hong Kong (China)
• ⁷⁰ The Chinese University of Hong Kong, Li Ka Shing Institute of Health Sciences, Hong Kong, China , Hong Kong (China)
• ⁷¹ The Chinese University of Hong Kong, Hong Kong Institute of Diabetes and Obesity, Hong Kong, China , Hong Kong (China)
• ⁷² Technische Universität München, Institute of Human Genetics, Munich, Germany , Munich (Germany)
• ⁷³ German Research Center for Environmental Health, Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
• ⁷⁴ Faculty of Medicine, Kuwait University, Health Science Center, Department of Biochemistry, Safat, Kuwait , Safat (Kuwait)
• ⁷⁵ University of Vermont, Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, Burlington, VT, USA , Burlington (United States)
• ⁷⁶ University of Vermont, Department of Biochemistry, The Robert Larner M.D. College of Medicine, Burlington, VT, USA , Burlington (United States)
• ⁷⁷ Harvard School of Public Health, Department of Nutrition, Boston, MA, USA , Boston (United States)
• ⁷⁸ University of Pennsylvania, Department of Biostatistics and Epidemiology, Philadelphia, PA, USA , Philadelphia (United States)
• ⁷⁹ Aarhus University, Department of Public Health, Aarhus, Denmark , Aarhus (Denmark)
• ⁸⁰ Danish Diabetes Academy, Odense, Denmark , Odense (Denmark)
• ⁸¹ Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore , Singapore (Singapore)
• ⁸² Duke-NUS Medical School Singapore, Singapore, Singapore , Singapore (Singapore)
• ⁸³ National University of Singapore, National University Health System, Department of Ophthalmology, Yong Loo Lin School of Medicine, Singapore, Singapore , Singapore (Singapore)
• ⁸⁴ Albert Einstein College of Medicine, Department of Medicine, New York, NY, USA , New York (United States)
• ⁸⁵ University of Haifa, Faculty of Natural Science, Haifa, Israel , Haifa (Israel)
• ⁸⁶ Albert Einstein College of Medicine, Department of Genetics, New York, NY, USA , New York (United States)
• ⁸⁷ University of Texas Rio Grande Valley, Department of Human Genetics, Edinburg, TX, USA , Edinburg (United States)
• ⁸⁸ South Texas Diabetes and Obesity Institute, Brownsville, TX, USA , Brownsville (United States)
• ⁸⁹ National Institutes of Health, Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA , Bethesda (United States)
• ⁹⁰ Imperial College London, Department of Epidemiology and Biostatistics, London, UK , London (United Kingdom)
• ⁹¹ Ealing Hospital NHS Trust, Department of Cardiology, Southall, UK , Southall (United Kingdom)
• ⁹² Imperial College London, Imperial College Healthcare NHS Trust, London, UK , London (United Kingdom)
• ⁹³ Duke-NUS Medical School, Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Singapore, Singapore , Singapore (Singapore)
• ⁹⁴ Hallym University, Department of Biomedical Science, Chuncheon, South Korea , Chuncheon (South Korea)
• ⁹⁵ Hadassah-Hebrew University Medical Center, Endocrinology and Metabolism Service, Jerusalem, Israel , Jerusalem (Israel)
• ⁹⁶ Instituto Nacional de Salud Pública, Unidad de Diabetes y Riesgo Cardiovascular, Cuernavaca, Mexico , Cuernavaca (Mexico)
• ⁹⁷ Centro de Estudios en Diabetes, Mexico City, Mexico , Mexico City (Mexico)
• ⁹⁸ University of Helsinki, Institute for Molecular Genetics Finland, Helsinki, Finland , Helsinki (Finland)
• ⁹⁹ Cardiovascular Sciences, Imperial College London, National Heart and Lung Institute, London, UK , London (United Kingdom)
• ¹⁰⁰ Seoul National University Hospital, Department of Internal Medicine, Seoul, South Korea , Seoul (South Korea)
• ¹⁰¹ Medicine, Lund University, Department of Clinical Sciences, Malmö, Sweden , Malmö (Sweden)
• ¹⁰² King’s College London, Department of Twin Research and Genetic Epidemiology, London, UK , London (United Kingdom)
• ¹⁰³ Folkhälsan Research Centre, Helsinki, Finland , Helsinki (Finland)
• ¹⁰⁴ Helsinki University Hospital, Department of Endocrinology, Abdominal Centre, Helsinki, Finland , Helsinki (Finland)
• ¹⁰⁵ University of Helsinki, Research Programs Unit, Diabetes and Obesity, Helsinki, Finland , Helsinki (Finland)
• ¹⁰⁶ National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland , Helsinki (Finland)
• ¹⁰⁷ Danube University Krems, Center for Vascular Prevention, Krems, Austria , Krems (Austria)
• ¹⁰⁸ King Abdulaziz University, Diabetes Research Group, Jeddah, Saudi Arabia , Jeddah (Saudi Arabia)
• ¹⁰⁹ University Hospital LaPaz, Autonomous University of Madrid, Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain , Madrid (Spain)
• ¹¹⁰ University of Mississippi Medical Center, Department of Physiology and Biophysics, Jackson, MS, USA , Jackson (United States)
• ¹¹¹ Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico , Mexico City (Mexico)
• ¹¹² Center for Non-Communicable Diseases, Karachi, Pakistan , Karachi (Pakistan)
• ¹¹³ Chungbuk National University, Department of Business Data Convergence, Gyeonggi-do, South Korea , Gyeonggi-do (South Korea)
• ¹¹⁴ Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Insititute, New York, NY, USA , New York (United States)
• ¹¹⁵ Ninewells Hospital and Medical School, Clinical Research Centre, Centre for Molecular Medicine, Dundee, UK , Dundee (United Kingdom)
• ¹¹⁶ VA Boston Healthcare, Section of Cardiology, Department of Medicine, Boston, MA, USA , Boston (United States)
• ¹¹⁷ Brigham and Women’s Hospital, Boston, MA, USA , Boston (United States)
• ¹¹⁸ National Heart Lung and Blood Institute, NIH, Intramural Administration Management Branch, Framingham, MA, USA , Framingham (United States)
• ¹¹⁹ Medical Research Institute, Ninewells Hospital and Medical School, Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Dundee, UK , Dundee (United Kingdom)
• ¹²⁰ University of Minnesota, Division of Epidemiology and Community Health, Minneapolis, MN, USA , Minneapolis (United States)
• ¹²¹ Seoul National University, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul, South Korea , Seoul (South Korea)
• ¹²² Seoul National University College of Medicine, Department of Internal Medicine, Seoul, South Korea , Seoul (South Korea)
• ¹²³ National University of Singapore, Life Sciences Institute, Singapore, Singapore , Singapore (Singapore)
• ¹²⁴ National University of Singapore, Department of Statistics and Applied Probability, Singapore, Singapore , Singapore (Singapore)
• ¹²⁵ University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA , Los Angeles (United States)
• ¹²⁶ The University of Texas Health Science Center at Houston, Human Genetics Center, School of Public Health, Houston, TX, USA , Houston (United States)
• ¹²⁷ Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Departamento de Medicina Genómica y Toxicología, Mexico City, Mexico , Mexico City (Mexico)
• ¹²⁸ German Research Center for Environmental Health, Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
• ¹²⁹ German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany , Neuherberg (Germany)
• ¹³⁰ Partner Site Munich Heart Alliance, Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Munich, Germany , Munich (Germany)
• ¹³¹ Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Neuherberg, Germany , Neuherberg (Germany)
• ¹³² University of Colorado Denver, Department of Medicine, Aurora, CO, USA , Aurora (United States)
• ¹³³ Faculty of Health and Medical Sciences, University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark , Copenhagen (Denmark)
• ¹³⁴ University of Southern Denmark, Faculty of Health Sciences, Odense, Denmark , Odense (Denmark)
• ¹³⁵ University of Colorado Anschutz Medical Campus, Department of Pediatrics, Aurora, CO, USA , Aurora (United States)
• ¹³⁶ Colorado School of Public Health, Department of Epidemiology, Aurora, CO, USA , Aurora (United States)
• ¹³⁷ Vanderbilt University, Vanderbilt Genetics Institute, Nashville, TN, USA , Nashville (United States)
• ¹³⁸ University of California, San Francisco, Department of Laboratory Medicine & Institute for Human Genetics, San Francisco, CA, USA , San Francisco (United States)
• ¹³⁹ Blood Systems Research Institute, San Francisco, CA, USA , San Francisco (United States)
• ¹⁴⁰ McGill University, Montreal, Department of Human Genetics, Quebec, Canada , Quebec (Canada)
• ¹⁴¹ McGill University, Division of Endocrinology and Metabolism, Department of Medicine, Montreal, Quebec, Canada , Montreal (Canada)
• ¹⁴² McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada , Montreal (Canada)
• ¹⁴³ Massachusetts General Hospital, Division of General Internal Medicine, Boston, MA, USA , Boston (United States)
• ¹⁴⁴ University of Virginia School of Medicine, Center for Public Health Genomics, Charlottesville, VA, USA , Charlottesville (United States)
• ¹⁴⁵ Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, CA, USA , Torrance (United States)
• ¹⁴⁶ Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Department of Medicine, Torrance, CA, USA , Torrance (United States)
• ¹⁴⁷ Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, USA , Torrance (United States)
• ¹⁴⁸ Harvard Medical School, Department of Genetics, Boston, MA, USA , Boston (United States)
• ¹⁴⁹ Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA , Cambridge (United States)
• ¹⁵⁰ Massachusetts General Hospital, Department of Molecular Biology, Boston, MA, USA , Boston (United States)
• ¹⁵¹ University of Liverpool, Department of Biostatistics, Liverpool, UK , Liverpool (United Kingdom)
• ¹⁵² Oxford University Hospitals Trust, Oxford NIHR Biomedical Research Centre, Oxford, UK , Oxford (United Kingdom)

Type

Published Article

Journal

Nature

Publisher

Springer Nature

Publication Date

May 22, 2019

Volume

570

Issue

7759

Pages

71–76

Identifiers

DOI: 10.1038/s41586-019-1231-2

Source

Springer Nature

License

Green