Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
- Authors
-
- Flannick, Jason1, 2, 3, 4
- Mercader, Josep M.1, 4, 5, 6, 7
- Fuchsberger, Christian8, 9, 10
- Udler, Miriam S.1, 4, 5, 6, 7
- Mahajan, Anubha11, 12
- Wessel, Jennifer13, 14, 15
- Teslovich, Tanya M.16
- Caulkins, Lizz1, 4
- Koesterer, Ryan1, 4
- Barajas-Olmos, Francisco17
- Blackwell, Thomas W.8, 10
- Boerwinkle, Eric18, 19
- Brody, Jennifer A.20
- Centeno-Cruz, Federico17
- Chen, Ling6, 7
- Chen, Siying8, 10
- Contreras-Cubas, Cecilia17
- Córdova, Emilio17
- Correa, Adolfo21
- Cortes, Maria22
- DeFronzo, Ralph A.23
- Dolan, Lawrence24
- Drews, Kimberly L.25
- Elliott, Amanda1, 4, 6, 7
- Floyd, James S.26
- Gabriel, Stacey22
- Garay-Sevilla, Maria Eugenia27, 28
- García-Ortiz, Humberto17
- Gross, Myron29
- Han, Sohee30
- Heard-Costa, Nancy L.31, 32
- Jackson, Anne U.8, 10
- Jørgensen, Marit E.33, 34, 35
- Kang, Hyun Min8, 10
- Kelsey, Megan25
- Kim, Bong-Jo30
- Koistinen, Heikki A.36, 37, 38
- Kuusisto, Johanna39, 40
- Leader, Joseph B.41
- Linneberg, Allan42, 43, 44
- Liu, Ching-Ti45
- Liu, Jianjun46, 47, 48
- Lyssenko, Valeriya49, 50
- Manning, Alisa K.7, 51
- Marcketta, Anthony16
- Malacara-Hernandez, Juan Manuel27, 28
- Martínez-Hernández, Angélica17
- Matsuo, Karen8, 10
- Mayer-Davis, Elizabeth52
- Mendoza-Caamal, Elvia17
- Mohlke, Karen L.53
- Morrison, Alanna C.18
- Ndungu, Anne11
- Ng, Maggie C. Y.54, 55, 56
- O’Dushlaine, Colm16
- Payne, Anthony J.11
- Pihoker, Catherine57
- Post, Wendy S.58
- Preuss, Michael59
- Psaty, Bruce M.60, 61, 62, 63, 64
- Vasan, Ramachandran S.32, 65
- Rayner, N. William11, 12, 66
- Reiner, Alexander P.63
- Revilla-Monsalve, Cristina67
- Robertson, Neil R.11, 12
- Santoro, Nicola68
- Schurmann, Claudia59
- So, Wing Yee69, 70, 71
- Soberón, Xavier17
- Stringham, Heather M.8, 10
- Strom, Tim M.72, 73
- Tam, Claudia H. T.69, 70, 71
- Thameem, Farook74
- Tomlinson, Brian69
- Torres, Jason M.11
- Tracy, Russell P.75, 76
- van Dam, Rob M.47, 48, 77
- Vujkovic, Marijana78
- Wang, Shuai45
- Welch, Ryan P.8, 10
- Witte, Daniel R.79, 80
- Wong, Tien-Yin81, 82, 83
- Atzmon, Gil84, 85, 86
- Barzilai, Nir84, 86
- Blangero, John87, 88
- Bonnycastle, Lori L.89
- Bowden, Donald W.54, 55, 56
- Chambers, John C.90, 91, 92
- Chan, Edmund47
- Cheng, Ching-Yu93
- Cho, Yoon Shin94
- Collins, Francis S.89
- de Vries, Paul S.18
- Duggirala, Ravindranath87, 88
- Glaser, Benjamin95
- Gonzalez, Clicerio96
- Gonzalez, Ma Elena97
- Groop, Leif49, 98
- Kooner, Jaspal Singh99
- Kwak, Soo Heon100
- Laakso, Markku39, 40
- Lehman, Donna M.23
- Nilsson, Peter101
- Spector, Timothy D.102
- Tai, E. Shyong47, 48, 82
- Tuomi, Tiinamaija98, 103, 104, 105
- Tuomilehto, Jaakko106, 107, 108, 109
- Wilson, James G.110
- Aguilar-Salinas, Carlos A.111
- Bottinger, Erwin59
- Burke, Brian25
- Carey, David J.41
- Chan, Juliana C. N.69, 70, 71
- Dupuis, Josée32, 45
- Frossard, Philippe112
- Heckbert, Susan R.60, 63
- Hwang, Mi Yeong30
- Kim, Young Jin30
- Kirchner, H. Lester41
- Lee, Jong-Young113
- Lee, Juyoung30
- Loos, Ruth J. F.59, 114
- Ma, Ronald C. W.69, 70, 71
- Morris, Andrew D.115
- O’Donnell, Christopher J.3, 116, 117, 118
- Palmer, Colin N. A.119
- Pankow, James120
- Park, Kyong Soo99, 121, 122
- Rasheed, Asif112
- Saleheen, Danish78, 112
- Sim, Xueling48
- Small, Kerrin S.102
- Teo, Yik Ying48, 123, 124
- Haiman, Christopher125
- Hanis, Craig L.126
- Henderson, Brian E.125
- Orozco, Lorena17
- Tusié-Luna, Teresa111, 127
- Dewey, Frederick E.16
- Baras, Aris16
- Gieger, Christian128, 129
- Meitinger, Thomas72, 73, 130
- Strauch, Konstantin128, 131
- Lange, Leslie132
- Grarup, Niels133
- Hansen, Torben133, 134
- Pedersen, Oluf133
- Zeitler, Philip135
- Dabelea, Dana136
- Abecasis, Goncalo8, 10
- Bell, Graeme I.27, 28
- Cox, Nancy J.137
- Seielstad, Mark138, 139
- Sladek, Rob140, 141, 142
- Meigs, James B.22, 7, 143
- Rich, Steve S.144
- Rotter, Jerome I.145, 146, 147
- Altshuler, David1, 4, 6, 7, 148, 149, 150
- Burtt, Noël P.1, 4
- Scott, Laura J.8, 10
- Morris, Andrew P.11, 151
- Florez, Jose C.1, 4, 5, 6, 7, 1
- McCarthy, Mark I.11, 12, 152
- Boehnke, Michael8, 10 And 144 more
- 1 Broad Institute, Program in Metabolism, Cambridge, MA, USA , Cambridge (United States)
- 2 Boston Children’s Hospital, Division of Genetics and Genomics, Boston, MA, USA , Boston (United States)
- 3 Harvard Medical School, Department of Pediatrics, Boston, MA, USA , Boston (United States)
- 4 Broad Institute, Program in Medical & Population Genetics, Cambridge, MA, USA , Cambridge (United States)
- 5 Massachusetts General Hospital, Center for Genomic Medicine, Boston, MA, USA , Boston (United States)
- 6 Massachusetts General Hospital, Diabetes Research Center (Diabetes Unit), Boston, MA, USA , Boston (United States)
- 7 Harvard Medical School, Department of Medicine, Boston, MA, USA , Boston (United States)
- 8 University of Michigan, Department of Biostatistics, Ann Arbor, MI, USA , Ann Arbor (United States)
- 9 Eurac Research, Institute for Biomedicine, Bolzano, Italy , Bolzano (Italy)
- 10 University of Michigan, Center for Statistical Genetics, Ann Arbor, MI, USA , Ann Arbor (United States)
- 11 University of Oxford, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, Oxford, UK , Oxford (United Kingdom)
- 12 University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Oxford, UK , Oxford (United Kingdom)
- 13 Indiana University, Department of Epidemiology, Fairbanks School of Public Health, Indianapolis, IN, USA , Indianapolis (United States)
- 14 Indiana University, Department of Medicine, School of Medicine, Indianapolis, IN, USA , Indianapolis (United States)
- 15 Indiana University, Diabetes Translational Research Center, Indianapolis, IN, USA , Indianapolis (United States)
- 16 Regeneron Pharmaceuticals, Regeneron Genetics Center, Tarrytown, NY, USA , Tarrytown (United States)
- 17 Instituto Nacional de Medicina Genómica, Mexico City, Mexico , Mexico City (Mexico)
- 18 The University of Texas Health Science Center at Houston, Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, Houston, TX, USA , Houston (United States)
- 19 Baylor College of Medicine, Human Genome Sequencing Center, Houston, TX, USA , Houston (United States)
- 20 University of Washington, Cardiovascular Research Unit, Department of Medicine, Seattle, WA, USA , Seattle (United States)
- 21 University of Mississippi Medical Center, Department of Medicine, Jackson, MS, USA , Jackson (United States)
- 22 Broad Institute of MIT and Harvard, Cambridge, MA, USA , Cambridge (United States)
- 23 University of Texas Health Science Center, Department of Medicine, San Antonio, TX, USA , San Antonio (United States)
- 24 Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA , Cincinnati (United States)
- 25 George Washington University, Biostatistics Center, Rockville, MD, USA , Rockville (United States)
- 26 University of Washington, Department of Medicine and Epidemiology, Seattle, WA, USA , Seattle (United States)
- 27 The University of Chicago, Department of Medicine, Chicago, IL, USA , Chicago (United States)
- 28 The University of Chicago, Department of Human Genetics, Chicago, IL, USA , Chicago (United States)
- 29 University of Minnesota, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA , Minneapolis (United States)
- 30 Center for Genome Science, National Institute of Health, Division of Genome Research, Chungcheongbuk-do, South Korea , Chungcheongbuk-do (South Korea)
- 31 Boston University School of Medicine, Department of Neurology, Boston, MA, USA , Boston (United States)
- 32 National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA , Framingham (United States)
- 33 Steno Diabetes Center Copenhagen, Gentofte, Denmark , Gentofte (Denmark)
- 34 University of Southern Denmark, National Institute of Public Health, Copenhagen, Denmark , Copenhagen (Denmark)
- 35 University of Greenland, Greenland Centre for Health Research, Nuuk, Greenland , Nuuk (Greenland)
- 36 National Institute for Health and Welfare, Department of Public Health Solutions, Helsinki, Finland , Helsinki (Finland)
- 37 Helsinki University Central Hospital, University of Helsinki and Department of Medicine, Helsinki, Finland , Helsinki (Finland)
- 38 Minerva Foundation Institute for Medical Research, Helsinki, Finland , Helsinki (Finland)
- 39 University of Eastern Finland, Institute of Clinical Medicine, Internal Medicine, Kuopio, Finland , Kuopio (Finland)
- 40 Kuopio University Hospital, Department of Medicin, Kuopio, Finland , Kuopio (Finland)
- 41 Geisinger Health System, Danville, PA, USA , Danville (United States)
- 42 University of Copenhagen, Department of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen, Denmark , Copenhagen (Denmark)
- 43 Bispebjerg and Frederiksberg Hospital, Center for Clinical Research and Prevention, Copenhagen, Denmark , Copenhagen (Denmark)
- 44 Rigshospitalet, Department of Clinical Experimental Research, Copenhagen, Denmark , Copenhagen (Denmark)
- 45 Boston University School of Public Health, Department of Biostatistics, Boston, MA, USA , Boston (United States)
- 46 Agency for Science Technology and Research, Genome Institute of Singapore, Singapore, Singapore , Singapore (Singapore)
- 47 National University of Singapore, National University Health System, Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore , Singapore (Singapore)
- 48 National University of Singapore, Saw Swee Hock School of Public Health, Singapore, Singapore , Singapore (Singapore)
- 49 Lund University Diabetes Centre, Department of Clinical Sciences, Diabetes and Endocrinology, Malmö, Sweden , Malmö (Sweden)
- 50 University of Bergen, Department of Clinical Science, Bergen, Norway , Bergen (Norway)
- 51 Massachusetts General Hospital, Harvard University, Clinical and Translational Epidemiology Unit, Boston, MA, USA , Boston (United States)
- 52 University of North Carolina Chapel Hill, Chapel Hill, NC, USA , Chapel Hill (United States)
- 53 University of North Carolina Chapel Hill, Department of Genetics, Chapel Hill, NC, USA , Chapel Hill (United States)
- 54 Wake Forest School of Medicine, Center for Diabetes Research, Winston-Salem, NC, USA , Winston-Salem (United States)
- 55 Wake Forest School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, NC, USA , Winston-Salem (United States)
- 56 Wake Forest School of Medicine, Department of Biochemistry, Winston-Salem, NC, USA , Winston-Salem (United States)
- 57 Seattle Children’s Hospital, Seattle, WA, USA , Seattle (United States)
- 58 Johns Hopkins University, Division of Cardiology, Department of Medicine, Baltimore, MD, USA , Baltimore (United States)
- 59 Mount Sinai School of Medicine, Charles R. Bronfman Institute of Personalized Medicine, New York, NY, USA , New York (United States)
- 60 University of Washington, Cardiovascular Health Research Unit, Seattle, WA, USA , Seattle (United States)
- 61 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA , Seattle (United States)
- 62 University of Washington, Department of Medicine, Seattle, WA, USA , Seattle (United States)
- 63 University of Washington, Department of Epidemiology, Seattle, WA, USA , Seattle (United States)
- 64 University of Washington, Department of Health Services, Seattle, WA, USA , Seattle (United States)
- 65 Boston University School of Medicine, Preventive Medicine & Epidemiology, Medicine, Boston, MA, USA , Boston (United States)
- 66 Wellcome Trust Sanger Institute, Department of Human Genetics, Hinxton, UK , Hinxton (United Kingdom)
- 67 Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico , Mexico City (Mexico)
- 68 Yale University, Department of Pediatrics, New Haven, CT, USA , New Haven (United States)
- 69 The Chinese University of Hong Kong, Department of Medicine and Therapeutics, Hong Kong, China , Hong Kong (China)
- 70 The Chinese University of Hong Kong, Li Ka Shing Institute of Health Sciences, Hong Kong, China , Hong Kong (China)
- 71 The Chinese University of Hong Kong, Hong Kong Institute of Diabetes and Obesity, Hong Kong, China , Hong Kong (China)
- 72 Technische Universität München, Institute of Human Genetics, Munich, Germany , Munich (Germany)
- 73 German Research Center for Environmental Health, Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
- 74 Faculty of Medicine, Kuwait University, Health Science Center, Department of Biochemistry, Safat, Kuwait , Safat (Kuwait)
- 75 University of Vermont, Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, Burlington, VT, USA , Burlington (United States)
- 76 University of Vermont, Department of Biochemistry, The Robert Larner M.D. College of Medicine, Burlington, VT, USA , Burlington (United States)
- 77 Harvard School of Public Health, Department of Nutrition, Boston, MA, USA , Boston (United States)
- 78 University of Pennsylvania, Department of Biostatistics and Epidemiology, Philadelphia, PA, USA , Philadelphia (United States)
- 79 Aarhus University, Department of Public Health, Aarhus, Denmark , Aarhus (Denmark)
- 80 Danish Diabetes Academy, Odense, Denmark , Odense (Denmark)
- 81 Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore , Singapore (Singapore)
- 82 Duke-NUS Medical School Singapore, Singapore, Singapore , Singapore (Singapore)
- 83 National University of Singapore, National University Health System, Department of Ophthalmology, Yong Loo Lin School of Medicine, Singapore, Singapore , Singapore (Singapore)
- 84 Albert Einstein College of Medicine, Department of Medicine, New York, NY, USA , New York (United States)
- 85 University of Haifa, Faculty of Natural Science, Haifa, Israel , Haifa (Israel)
- 86 Albert Einstein College of Medicine, Department of Genetics, New York, NY, USA , New York (United States)
- 87 University of Texas Rio Grande Valley, Department of Human Genetics, Edinburg, TX, USA , Edinburg (United States)
- 88 South Texas Diabetes and Obesity Institute, Brownsville, TX, USA , Brownsville (United States)
- 89 National Institutes of Health, Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD, USA , Bethesda (United States)
- 90 Imperial College London, Department of Epidemiology and Biostatistics, London, UK , London (United Kingdom)
- 91 Ealing Hospital NHS Trust, Department of Cardiology, Southall, UK , Southall (United Kingdom)
- 92 Imperial College London, Imperial College Healthcare NHS Trust, London, UK , London (United Kingdom)
- 93 Duke-NUS Medical School, Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Singapore, Singapore , Singapore (Singapore)
- 94 Hallym University, Department of Biomedical Science, Chuncheon, South Korea , Chuncheon (South Korea)
- 95 Hadassah-Hebrew University Medical Center, Endocrinology and Metabolism Service, Jerusalem, Israel , Jerusalem (Israel)
- 96 Instituto Nacional de Salud Pública, Unidad de Diabetes y Riesgo Cardiovascular, Cuernavaca, Mexico , Cuernavaca (Mexico)
- 97 Centro de Estudios en Diabetes, Mexico City, Mexico , Mexico City (Mexico)
- 98 University of Helsinki, Institute for Molecular Genetics Finland, Helsinki, Finland , Helsinki (Finland)
- 99 Cardiovascular Sciences, Imperial College London, National Heart and Lung Institute, London, UK , London (United Kingdom)
- 100 Seoul National University Hospital, Department of Internal Medicine, Seoul, South Korea , Seoul (South Korea)
- 101 Medicine, Lund University, Department of Clinical Sciences, Malmö, Sweden , Malmö (Sweden)
- 102 King’s College London, Department of Twin Research and Genetic Epidemiology, London, UK , London (United Kingdom)
- 103 Folkhälsan Research Centre, Helsinki, Finland , Helsinki (Finland)
- 104 Helsinki University Hospital, Department of Endocrinology, Abdominal Centre, Helsinki, Finland , Helsinki (Finland)
- 105 University of Helsinki, Research Programs Unit, Diabetes and Obesity, Helsinki, Finland , Helsinki (Finland)
- 106 National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland , Helsinki (Finland)
- 107 Danube University Krems, Center for Vascular Prevention, Krems, Austria , Krems (Austria)
- 108 King Abdulaziz University, Diabetes Research Group, Jeddah, Saudi Arabia , Jeddah (Saudi Arabia)
- 109 University Hospital LaPaz, Autonomous University of Madrid, Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), Madrid, Spain , Madrid (Spain)
- 110 University of Mississippi Medical Center, Department of Physiology and Biophysics, Jackson, MS, USA , Jackson (United States)
- 111 Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico , Mexico City (Mexico)
- 112 Center for Non-Communicable Diseases, Karachi, Pakistan , Karachi (Pakistan)
- 113 Chungbuk National University, Department of Business Data Convergence, Gyeonggi-do, South Korea , Gyeonggi-do (South Korea)
- 114 Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Insititute, New York, NY, USA , New York (United States)
- 115 Ninewells Hospital and Medical School, Clinical Research Centre, Centre for Molecular Medicine, Dundee, UK , Dundee (United Kingdom)
- 116 VA Boston Healthcare, Section of Cardiology, Department of Medicine, Boston, MA, USA , Boston (United States)
- 117 Brigham and Women’s Hospital, Boston, MA, USA , Boston (United States)
- 118 National Heart Lung and Blood Institute, NIH, Intramural Administration Management Branch, Framingham, MA, USA , Framingham (United States)
- 119 Medical Research Institute, Ninewells Hospital and Medical School, Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Dundee, UK , Dundee (United Kingdom)
- 120 University of Minnesota, Division of Epidemiology and Community Health, Minneapolis, MN, USA , Minneapolis (United States)
- 121 Seoul National University, Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul, South Korea , Seoul (South Korea)
- 122 Seoul National University College of Medicine, Department of Internal Medicine, Seoul, South Korea , Seoul (South Korea)
- 123 National University of Singapore, Life Sciences Institute, Singapore, Singapore , Singapore (Singapore)
- 124 National University of Singapore, Department of Statistics and Applied Probability, Singapore, Singapore , Singapore (Singapore)
- 125 University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA , Los Angeles (United States)
- 126 The University of Texas Health Science Center at Houston, Human Genetics Center, School of Public Health, Houston, TX, USA , Houston (United States)
- 127 Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Departamento de Medicina Genómica y Toxicología, Mexico City, Mexico , Mexico City (Mexico)
- 128 German Research Center for Environmental Health, Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany , Neuherberg (Germany)
- 129 German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany , Neuherberg (Germany)
- 130 Partner Site Munich Heart Alliance, Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Munich, Germany , Munich (Germany)
- 131 Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Neuherberg, Germany , Neuherberg (Germany)
- 132 University of Colorado Denver, Department of Medicine, Aurora, CO, USA , Aurora (United States)
- 133 Faculty of Health and Medical Sciences, University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark , Copenhagen (Denmark)
- 134 University of Southern Denmark, Faculty of Health Sciences, Odense, Denmark , Odense (Denmark)
- 135 University of Colorado Anschutz Medical Campus, Department of Pediatrics, Aurora, CO, USA , Aurora (United States)
- 136 Colorado School of Public Health, Department of Epidemiology, Aurora, CO, USA , Aurora (United States)
- 137 Vanderbilt University, Vanderbilt Genetics Institute, Nashville, TN, USA , Nashville (United States)
- 138 University of California, San Francisco, Department of Laboratory Medicine & Institute for Human Genetics, San Francisco, CA, USA , San Francisco (United States)
- 139 Blood Systems Research Institute, San Francisco, CA, USA , San Francisco (United States)
- 140 McGill University, Montreal, Department of Human Genetics, Quebec, Canada , Quebec (Canada)
- 141 McGill University, Division of Endocrinology and Metabolism, Department of Medicine, Montreal, Quebec, Canada , Montreal (Canada)
- 142 McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada , Montreal (Canada)
- 143 Massachusetts General Hospital, Division of General Internal Medicine, Boston, MA, USA , Boston (United States)
- 144 University of Virginia School of Medicine, Center for Public Health Genomics, Charlottesville, VA, USA , Charlottesville (United States)
- 145 Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Department of Pediatrics, Torrance, CA, USA , Torrance (United States)
- 146 Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Department of Medicine, Torrance, CA, USA , Torrance (United States)
- 147 Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, USA , Torrance (United States)
- 148 Harvard Medical School, Department of Genetics, Boston, MA, USA , Boston (United States)
- 149 Massachusetts Institute of Technology, Department of Biology, Cambridge, MA, USA , Cambridge (United States)
- 150 Massachusetts General Hospital, Department of Molecular Biology, Boston, MA, USA , Boston (United States)
- 151 University of Liverpool, Department of Biostatistics, Liverpool, UK , Liverpool (United Kingdom)
- 152 Oxford University Hospitals Trust, Oxford NIHR Biomedical Research Centre, Oxford, UK , Oxford (United Kingdom)
- Type
- Published Article
- Journal
- Nature
- Publisher
- Springer Nature
- Publication Date
- May 22, 2019
- Volume
- 570
- Issue
- 7759
- Pages
- 71–76
- Identifiers
- DOI: 10.1038/s41586-019-1231-2
- Source
- Springer Nature
- License
- Green
Abstract
Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.