The role of endogenous TNFalpha in the induction and propagation of arthritis is well established. However, exogenous TNFalpha can down modulate the course of AA, displaying an immunoregulatory functional attribute of this cytokine.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/08/2017 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18380898