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Exiguous premeal saccharide intake reduces subsequent food intake in men.

Authors
  • Richter, Juliane1
  • Thordsen, Narona2
  • Duysen, Kai2
  • Oltmanns, Kerstin M2
  • 1 Section of Psychoneurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of Luebeck, Ratzeburger Allee 160, 23562, Luebeck, Germany. [email protected] , (Germany)
  • 2 Section of Psychoneurobiology, Center of Brain, Behavior and Metabolism (CBBM), University of Luebeck, Ratzeburger Allee 160, 23562, Luebeck, Germany. , (Germany)
Type
Published Article
Journal
European Journal of Nutrition
Publisher
Springer-Verlag
Publication Date
Oct 01, 2021
Volume
60
Issue
7
Pages
3887–3895
Identifiers
DOI: 10.1007/s00394-021-02563-7
PMID: 33891230
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Satiety is a crucial factor in the attempt to reduce food intake for long-term body weight loss. Since there is evidence for a negative correlation between cerebral energy levels and food intake, the provision of the primary energy substrate glucose to the brain through oral ingestion of carbohydrates could trigger feelings of satiety. Therefore, we hypothesized that a low-calorie saccharide preload would increase satiety, reduce subsequent food intake, and thereby decrease overall calorie consumption. In a randomized single-blind crossover study, 17 healthy young normal-weight men received saccharide (26 kcal in total) or placebo capsules 30 min before a standardized breakfast buffet. We analysed food intake from the test buffet as well as plasma glucose and serum insulin levels. The saccharide preload reduced food intake from the buffet by 168 (± 34) kcal (p < 0.001) compared to control. This corresponds to a net reduction in total calorie consumption by 142 (± 34) kcal (p < 0.001) or 9.3% due to saccharide capsules. A very low-calorie saccharide preload considerably reduces subsequent food intake leading to decreased overall calorie consumption. A saccharide preload before meals could, therefore, be a promising support for reducing caloric intake. DRKS00010281 (date of registration: 11.04.2016). © 2021. The Author(s).

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