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Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

  • Alves, Christiano R.R.1, 2, 3
  • Neves, Willian das1, 4
  • de Almeida, Ney R.1
  • Eichelberger, Eric J.3
  • Jannig, Paulo R.1, 5
  • Voltarelli, Vanessa A.1
  • Tobias, Gabriel C.1
  • Bechara, Luiz R.G.1
  • de Paula Faria, Daniele6
  • Alves, Maria J.N.7
  • Hagen, Lars8, 9
  • Sharma, Animesh8, 9
  • Slupphaug, Geir8, 9
  • Moreira, José B.N.10
  • Wisloff, Ulrik10
  • Hirshman, Michael F.2
  • Negrão, Carlos E.1, 7
  • de Castro Jr, Gilberto4
  • Chammas, Roger6
  • Swoboda, Kathryn J.3
  • And 3 more
  • 1 School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil
  • 2 Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
  • 3 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
  • 4 Instituto do Cancer do Estado de Sao Paulo ICESP, Hospital das Clinicas HC FMUSP, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
  • 5 Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
  • 6 Department of Radiology and Oncology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
  • 7 Heart Institute, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
  • 8 Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
  • 9 Proteomics and Modomics Experimental Core, PROMEC, at NTNU and the Central Norway Regional Health Authority, Stjørdal, Norway
  • 10 K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
Published Article
Molecular Metabolism
Elsevier BV
Publication Date
May 11, 2020
DOI: 10.1016/j.molmet.2020.101012
PMID: 32408015
PMCID: PMC7283151
PubMed Central


• Exercise training prolongs lifespan, reduces oxidative stress, and improves skeletal muscle function in tumor-bearing rats. • Muscle COP9 signalosome complex subunit 2 (COPS2) protein is downregulated in cancer cachexia. • Exercise training restores COPS2 protein expression to control levels. • Cancer-conditioned media decreased F-actin expression in myotubes, which is partially restored by COPS2 knockdown. • COPS2 overexpression decreases DR4 activity and COPS2 knockdown inhibits cancer-conditioned media effects on DR4 activity.

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