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Exercise interventions for older adults with Alzheimer’s disease: a systematic review and meta-analysis protocol

  • Faieta, Julie M.1, 2
  • Devos, Hannes3
  • Vaduvathiriyan, Prasanna3
  • York, Michele K.4
  • Erickson, Kirk I.5
  • Hirsch, Mark A.6
  • Downer, Brian G.7
  • van Wegen, Erwin E. H.8
  • Wong, Diana C.9
  • Philippou, Elena10
  • Negm, Ahmed11
  • Ahmadnezhad, Pedram3
  • Krishnan, Shilpa12
  • Kahya, Melike3
  • Sood, Pallavi13
  • Heyn, Patricia C.14
  • 1 Université Laval, Quebec, Canada , Quebec (Canada)
  • 2 Centre interdisciplinaire de recherche en réadaptation et en intégration sociale (CIRRIS), Québec, Canada , Québec (Canada)
  • 3 University of Kansas Medical Center, Kansas City, USA , Kansas City (United States)
  • 4 Baylor College of Medicine, Houston, USA , Houston (United States)
  • 5 University of Pittsburgh, Pittsburgh, USA , Pittsburgh (United States)
  • 6 Carolinas Medical Center/Carolinas Rehabilitation, Charlotte, USA , Charlotte (United States)
  • 7 University of Texas Medical Branch, Galveston, USA , Galveston (United States)
  • 8 Amsterdam Movement Sciences, Amsterdam, Netherlands , Amsterdam (Netherlands)
  • 9 New York University, New York, USA , New York (United States)
  • 10 University of Nicosia, Nicosia, Cyprus , Nicosia (Cyprus)
  • 11 University of Alberta, Edmonton, Canada , Edmonton (Canada)
  • 12 Emory University, Atlanta, USA , Atlanta (United States)
  • 13 University of Florida, Gainesville, USA , Gainesville (United States)
  • 14 University of Colorado Anschutz Medical Campus, Aurora, USA , Aurora (United States)
Published Article
Systematic Reviews
BioMed Central
Publication Date
Jan 04, 2021
DOI: 10.1186/s13643-020-01555-8
Springer Nature


BackgroundThe growing societal and economic impact of Alzheimer’s disease (AD) is further compounded by the present lack of disease-modifying interventions. Non-pharmacological intervention approaches, such as exercise, have the potential to be powerful approaches to improve or mitigate the symptoms of AD without added side effects or financial burden associated with drug therapies. Various forms and regiments of exercise (i.e., strength, aerobic, multicomponent) have been reported in the literature; however, conflicting evidence obscures clear interpretation of the value and impact of exercise as an intervention for older adults with AD. The primary objective of this review will be to evaluate the effects of exercise interventions for older adults with AD. In addition, this review will evaluate the evidence quality and synthesize the exercise training prescriptions for proper clinical practice guidelines and recommendations.MethodsThis systematic review and meta-analysis will be carried out by an interdisciplinary collective representing clinical and research stakeholders with diverse expertise related to neurodegenerative diseases and rehabilitation medicine. Literature sources will include the following: Embase, PsychINFO, OVID Medline, and Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily. Inclusion criteria are participants with late onset AD and structured exercise interventions with prescribed duration, frequency, and intensity. The primary outcome of this study will center on improved or sustained cognitive functioning. Secondary outcomes will include institutionalization-related outcomes, ability in activities of daily living, mood and emotional well-being, quality of life, morbidity, and mortality. Analysis procedures to include measurement of bias, data synthesis, sensitivity analysis, and assessment of heterogeneity are described in this protocol.DiscussionThis review is anticipated to yield clinically meaningful insight on the specific value of exercise for older adults with AD. Improved understanding of diverse exercise intervention approaches and their specific impact on various health- and function-related outcomes is expected to guide clinicians to more frequently and accurately prescribe meaningful interventions for those affected by AD.Systematic review registrationPROSPERO CRD42020175016.

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