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Exendin-4 analogs in insulinoma theranostics

Authors
  • Jansen, Tom JP;
  • van Lith, Sanne AM;
  • Boss, Marti;
  • Brom, Maarten;
  • Joosten, Lieke;
  • Behe, Martin;
  • Buitinga, Mijke; 115520;
  • Gotthardt, Martin;
Publication Date
Aug 01, 2019
Source
Lirias
Keywords
License
Unknown
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Abstract

Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy. / status: published

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