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Excessive expressions of T cell activation markers in pediatric immune thrombocytopenia.

Authors
  • Chen, Yuanyuan1
  • Zhou, Yanqiong1
  • Chen, Ping1
  • Zhang, Ping1
  • Jia, Ming1
  • Tang, Yongmin2
  • 1 Division of Hematology-oncology, Children's Hospital of Zhejiang University School of Medicine, #57 Zhuganxiang Road, Hangzhou 310003, PR China. , (China)
  • 2 Division of Hematology-oncology, Children's Hospital of Zhejiang University School of Medicine, #57 Zhuganxiang Road, Hangzhou 310003, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Thrombosis research
Publication Date
May 15, 2019
Volume
180
Pages
1–9
Identifiers
DOI: 10.1016/j.thromres.2019.05.010
PMID: 31146120
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder in children. Activated T cells have been shown to play important roles in ITP. The aims of this study were to evaluate whether these T cell activation markers could be used as indicators to differentiate ITP patients from controls, and to assess whether they could be used as predictors of IVIG response in ITP patients. A cohort of 92 hospitalized ITP patients, 49 unrelated healthy children, and 48 thrombocytosis patients were enrolled in this retrospective study between February 2013 and September 2018. Expression of CD25, HLA-DR, and CD69 on the surfaces of CD4+ and CD8+ T cells were detected by flow cytometry. All statistical analyses were performed using SPSS 20.0 software. Compared to the healthy controls, ITP patients had higher percentages of CD4 + CD25+ T cells, CD4 + HLA-DR+ T cells, CD8 + HLA-DR+ T cells, and CD8 + CD69+ T cells. Compared to the thrombocytosis patients, ITP patients had higher percentages of CD4 + HLA-DR+ T cells and CD8 + HLA-DR+ T cells, and lower CD4 + CD69+ T cells and CD8 + CD69+ T cells. Platelet count at admission had a negative correlation with CD4 + CD25+ T cells in ITP. CD4 + CD69+ T cells were decreased in chronic compared to the newly diagnosed and persistent ITP patients. Activated T cell markers had no predictive value for IVIG response in ITP patients. T cell activation markers were excessively expressed in pediatric ITP, and those markers had no predictive value for IVIG response in ITP patients. Copyright © 2019 Elsevier Ltd. All rights reserved.

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