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An examination of the relationship between regulatory T cells and symptom flare-ups in children and adolescents diagnosed with chronic tic disorder and Tourette syndrome.

Authors
  • Yildirim, Zeynep1
  • Karabekiroglu, Koray2
  • Yildiran, Alisan3
  • Celiksoy, Mehmet Halil3
  • Artukoglu, Bekir4
  • Baykal, Saliha5
  • Babadağı, Zehra6
  • Leckman, James4
  • 1 Department of Child and Adolescent Psychiatry, Medikal Park Hospital, Samsun, Turkey. , (Turkey)
  • 2 Department of Child and Adolescent Psychiatry, Ondokuz Mayis University, Samsun, Turkey. , (Turkey)
  • 3 Division of Pediatric Allergy and Immunology, Ondokuz Mayis University, Samsun, Turkey. , (Turkey)
  • 4 Yale Child Study Center, New Haven, CT, USA.
  • 5 Department of Child and Adolescent Psychiatry, Namik Kemal University, Tekirdag, Turkey. , (Turkey)
  • 6 Department of Child and Adolescent Psychiatry, Kayseri Education and Research Hospital, Kayseri, Turkey. , (Turkey)
Type
Published Article
Journal
Nordic Journal of Psychiatry
Publisher
Informa UK (Taylor & Francis)
Publication Date
Jan 01, 2021
Volume
75
Issue
1
Pages
18–24
Identifiers
DOI: 10.1080/08039488.2020.1779808
PMID: 32580599
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by several motor and phonic tics. In this study, we aimed to compare activated regulatory T cell (Treg) values between patients with TS/chronic tic disorder (CTD) and age- and sex-matched healthy controls (HCs). Patients with TS/CTD and age- and sex-matched HCs were included in the study. The severity of the disease was evaluated using the Yale Global Tic Severity Scale. CD4+CD25+CD127low Tregs from the patient group and the control group were compared using flow cytometry. The study included 48 patients diagnosed with TS/CTD (36 males and 12 females, mean age: 11.58 ± 2.61) and 24 HCs (18 males and 6 females, mean age: 11.63 ± 2.60). The TS/CTD group had significantly higher activated regulatory T percentile with respect to the T helper value compared to the HCs (p = 0.010). Lymphocyte count, T lymphocyte count, T lymphocyte percentage, T-helper lymphocyte count, and T-helper lymphocyte percentage were lower in the patient group compared to the control group (p = 0.024, 0.003, 0.007, <0.001, <0.001, respectively). The comparison of three groups (mild, moderate-severe, and HCs) revealed that T lymphocyte number and percentage and the T helper number and percentage were significantly higher in the HC group compared to the moderate-severe group, whereas the activated Treg percentage with respect to the T helper value was significantly higher in the moderate-severe group compared to the HC group (0.002, 0.026, <0.001, <0.001, 0.027, respectively). Our results suggest that Tregs may have a role in the pathogenesis of TS/CTD.

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