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Ex vivo culture of human fetal gonads: manipulation of meiosis signalling by retinoic acid treatment disrupts testis development.

Authors
  • Jørgensen, A1
  • Nielsen, J E2
  • Perlman, S3
  • Lundvall, L3
  • Mitchell, R T4
  • Juul, A2
  • Rajpert-De Meyts, E2
  • 1 University Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark [email protected] , (Denmark)
  • 2 University Department of Growth and Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. , (Denmark)
  • 3 Department of Gynaecology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen DK-2100, Denmark. , (Denmark)
  • 4 MRC Centre for Reproductive Health, The University of Edinburgh, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK Edinburgh Royal Hospital for Sick Children, 9 Sciennes Road, Edinburgh EH9 1LF, UK. , (France)
Type
Published Article
Journal
Human Reproduction
Publisher
Oxford University Press
Publication Date
Oct 01, 2015
Volume
30
Issue
10
Pages
2351–2363
Identifiers
DOI: 10.1093/humrep/dev194
PMID: 26251460
Source
Medline
Keywords
License
Unknown

Abstract

This work was supported in part by an ESPE Research Fellowship, sponsored by Novo Nordisk A/S to A.Jø. Additional funding for this project was obtained from The Research Council of the Capital Region of Denmark (E.R.-D.M.), The Research Fund at Rigshospitalet (A.Ju. and J.E.N.), Familien Erichssens Fund (A.Jø.), Dagmar Marshalls Fund (A.Jø.) and Aase & Ejnar Danielsens Fund (A.Jø.). The authors have no conflicts of interest.

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