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Evolutionary rationale for phases as complements of antibiotics

Authors
  • Torres-Barceló, Clara
  • Hochberg, Michael E.
Publication Date
Jan 01, 2016
Identifiers
DOI: 10.1016/j.tim.2015.12.011
PMID: 26786863
OAI: oai:HAL:hal-02639673v1
Source
HAL-Descartes
Keywords
Language
English
License
Unknown
External links

Abstract

Antibiotic-resistant bacterial infections are a major concern to public health. Phage therapy has been proposed as a promising alternative to antibiotics, but an increasing number of studies suggest that both of these antimicrobial agents in combination are more effective in controlling pathogenic bacteria than either alone. We advocate the use of phages in combination with antibiotics and present the evolutionary basis for our claim. In addition, we identify compelling challenges for the realistic application of phage-antibiotic combined therapy.

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