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Evolutionary history of Pneumocystis fungi in their African rodent hosts.

Authors
  • Petružela, Jan1
  • Bryja, Josef2
  • Bryjová, Anna3
  • Katakweba, Abdul4
  • Sabuni, Christopher4
  • Baird, Stuart J E3
  • de Bellocq, Joëlle Goüy3
  • 1 Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic; Faculty of Science, Department of Botany and Zoology, Masaryk University, Brno, Czech Republic. Electronic address: [email protected] , (Czechia)
  • 2 Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic; Faculty of Science, Department of Botany and Zoology, Masaryk University, Brno, Czech Republic. , (Czechia)
  • 3 Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, Brno, Czech Republic. , (Czechia)
  • 4 Pest Management Centre, Sokoine University of Agriculture, Morogoro, Tanzania. , (Tanzania)
Type
Published Article
Journal
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Publication Date
Jun 24, 2019
Volume
75
Pages
103934–103934
Identifiers
DOI: 10.1016/j.meegid.2019.103934
PMID: 31247340
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Pneumocystis is a genus of parasitic fungi infecting lung tissues in a wide range of mammal species, displaying a strong host specificity and patterns of co-speciation with their hosts. However, a recent study on Asiatic murids challenged these patterns reporting several Pneumocystis lineages/species shared by different host species or even genera in the Rattini and Murini tribes. Here we screened lung samples of 27 species of African rodents from five families for the presence of Pneumocystis DNA. Using reconstructed multi-locus phylogenies of both hosts and parasites, we tested the hypothesis of their co-evolution. We found that Pneumocystis is widespread in African rodents, detected in all but seven screened host species, with species-level prevalence ranging from 5.9 to 100%. Several host species carry pairs of highly divergent Pneumocystis lineages/species. The retrieved co-phylogenetic signal was highly significant (p = .0017). We found multiple co-speciations, sorting events and two host-shift events, which occurred between Murinae and Deomyinae hosts. Comparison of genetic distances suggests higher substitution rates for Pneumocystis relative to the rodent hosts on neutral loci and slower rates on selected ones. We discuss life-history traits and population dynamics factors which could explain the observed results. Copyright © 2019 Elsevier B.V. All rights reserved.

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