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Evolutionary and biomedical insights from the rhesus macaque genome.

Authors
  • K, Hirani
  • H, Kehrer-Sawatzki
  • J, Kolb
  • S, Patil
  • Ll, Pu
  • Y, Ren
  • Dg, Smith
  • Da, Wheeler
  • I, Schenck
  • Ev, Ball
  • R, Chen
  • Dn, Cooper
  • B, Giardine
  • F, Hsu
  • Wj, Kent
  • A, Lesk
  • Dl, Nelson
  • We, O Brien
  • K, Prüfer
  • Pd, Stenson
  • And 157 more
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Volume
316
Issue
5822
Pages
222–234
Source
UCSC Bioinformatics biomedical-ucsc
License
Unknown

Abstract

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

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