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[Evolutionary admonition: allergy].

Authors
  • Gushchin, I S
Type
Published Article
Journal
Patologicheskaia fiziologiia i èksperimental'naia terapiia
Publication Date
Jan 01, 2014
Issue
1
Pages
57–67
Identifiers
PMID: 25051686
Source
Medline
License
Unknown

Abstract

The paper concerns phylogeny development of allergic reactivity, the most probable antecedents of allergic IgE antibodies, high affinity IgE receptor (Fc(epsilon)RI), presents comparative character of IgE - Fc(epsilon)RI and IgY- CHIR-AB1 interactions. The paper has given an insight of allergy as evolutionary selected reactivity for highly organized animals. This reactivity is directed to organization of allergen-specific inflammation and serves as biologically expedient, high-specific and high-sensitive reaction in response to allergen entering into the organism because of barrier tissue dysfunction. Such insight has raised a question on consequences of thoroughgoing allergy reactivity elimination for highly organized animals and their posterity.

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