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The evolution of seasonal influenza viruses.

Authors
  • Petrova, Velislava N1
  • Russell, Colin A2, 3
  • 1 Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • 2 Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.
  • 3 Laboratory of Applied Evolutionary Biology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Jan 01, 2018
Volume
16
Issue
1
Pages
47–60
Identifiers
DOI: 10.1038/nrmicro.2017.118
PMID: 29081496
Source
Medline
License
Unknown

Abstract

Despite decades of surveillance and pharmaceutical and non-pharmaceutical interventions, seasonal influenza viruses continue to cause epidemics around the world each year. The key process underlying these recurrent epidemics is the evolution of the viruses to escape the immunity that is induced by prior infection or vaccination. Although we are beginning to understand the processes that underlie the evolutionary dynamics of seasonal influenza viruses, the timing and nature of emergence of new virus strains remain mostly unpredictable. In this Review, we discuss recent advances in understanding the molecular determinants of influenza virus immune escape, sources of evolutionary selection pressure, population dynamics of influenza viruses and prospects for better influenza virus control.

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