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Evolution and Revolution of Hepatitis C Management: From Non-A, Non-B Hepatitis Toward Global Elimination

Authors
  • Basyte-Bacevice, Viktorija
  • Kupcinskas, Juozas
Type
Published Article
Journal
Digestive Diseases
Publisher
S. Karger AG
Publication Date
Jan 06, 2020
Volume
38
Issue
2
Pages
137–142
Identifiers
DOI: 10.1159/000505434
Source
Karger
Keywords
License
Green
External links

Abstract

Discovery of hepatitis C in 1989 allowed basic research to identify critical components of hepatitis C virus (HCV) structure and life cycle. Interferon (IFN)-α was introduced as first treatment for chronic hepatitis C and later was enhanced by pegylation, addition of ribavirin, and resulted in improved sustained virologic response. Better understanding of HCV structure, enzymes, and lifecycle led to the discovery of direct-acting antivirals and IFN-free era. Successful HCV therapy created a rare possibility of global disease eradication, which is now a major goal internationally. However, hepatitis C remains a major public health challenge, and more resources are needed to reach global elimination.

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