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The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting.

Authors
  • White, P Lewis
  • Linton, Christopher J
  • Perry, Michael D
  • Johnson, Elizabeth M
  • Barnes, Rosemary A
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Feb 15, 2006
Volume
42
Issue
4
Pages
479–486
Identifiers
PMID: 16421791
Source
Medline
License
Unknown

Abstract

A negative PCR result can be used to rule out IA and to limit the need for empirical antifungal therapy; thus, it has a role in diagnosing IA infections, especially in combination with antigen testing. PCR-positive cases classified as "false positives" regularly reflect the limitations of classic microbiological procedures or restricted use of consensus clinical methods employed to classify infection.

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