An original nephrological scientific conception of E. M. Tareev developed in five stages. Stage one (1917-1929) is a functional-physiological approach to renal pathology. The first book devoted to this problem was "Bright' Disease" (1929). At stage II (1929-1936) E. M. Tareev closely investigated pathogenesis and clinical aspects of renal diseases. His views at that time were reflected in the book "Renal Diseases" (1936). Fundamental, experimental and clinical basis of the nephrological conception was formulated at stage III (1936-1952). At stage IV (1952-1968) E. M. Tareev proposed a new classification of renal diseases presented in the book "Nephritides" (1958). Stage V (1968-1986) was devoted to the integrating role of nephrology. Two books "Fundamentals of Nephrology" (1972) and "Clinical Nephrology" (1983) contributed much to fundamentals of current nephrology.